Detalhe da pesquisa
1.
Antagonism of supraspinal histamine H3 receptors modulates spinal neuronal activity in neuropathic rats.
J Pharmacol Exp Ther
; 343(1): 13-20, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22729221
2.
Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
J Pharmacol Exp Ther
; 343(1): 233-45, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815533
3.
Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease.
J Pharmacol Exp Ther
; 336(1): 38-46, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864505
4.
In vitro studies on a class of quinoline containing histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(11): 3295-300, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457525
5.
A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.
Assay Drug Dev Technol
; 6(3): 339-49, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18593375
6.
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Bioorg Med Chem Lett
; 18(1): 355-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077160
7.
An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity.
J Pharmacol Exp Ther
; 323(3): 888-98, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855474
8.
Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.
J Med Chem
; 50(22): 5439-48, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918921
9.
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
J Med Chem
; 49(23): 6726-31, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154503
10.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
J Med Chem
; 49(25): 7450-65, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149874
11.
Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
Eur J Pharmacol
; 540(1-3): 115-20, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16765941
12.
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
J Med Chem
; 59(10): 4926-47, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27077528
13.
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Neuropharmacology
; 49(1): 112-21, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15992586
14.
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
J Med Chem
; 47(9): 2348-55, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084133
15.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic Clin Pharmacol Toxicol
; 95(3): 144-52, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15447739
16.
Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems.
Brain Res
; 1354: 74-84, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20682302
17.
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
J Med Chem
; 53(21): 7869-73, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20945906
18.
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats.
Pharmacol Biochem Behav
; 95(1): 41-50, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004681
19.
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.
J Med Chem
; 52(15): 4640-9, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19588934
20.
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
J Med Chem
; 51(17): 5423-30, 2008 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18683917