Detalhe da pesquisa
1.
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.
Cell
; 173(4): 958-971.e17, 2018 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29628143
2.
SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
Brain
; 147(1): 109-121, 2024 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37639327
3.
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.
Acta Neuropathol
; 147(1): 1, 2023 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38019311
4.
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.
Hum Mol Genet
; 24(24): 6886-98, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385636
5.
Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.
J Neurosci
; 34(48): 15962-74, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25429138
6.
A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.
PLoS Genet
; 12(11): e1006419, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27855157
7.
Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease.
Nucleus
; 15(1): 2349085, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700207
8.
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Nat Neurosci
; 27(4): 643-655, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38424324
9.
Nuclear pore complex and nucleocytoplasmic transport disruption in neurodegeneration.
FEBS Lett
; 597(20): 2546-2566, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37657945
10.
Highly variable molecular signatures of TDP-43 loss of function are associated with nuclear pore complex injury in a population study of sporadic ALS patient iPSNs.
bioRxiv
; 2023 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168312
11.
Nuclear pore complexes - a doorway to neural injury in neurodegeneration.
Nat Rev Neurol
; 18(6): 348-362, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35488039
12.
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Sci Transl Med
; 14(662): eabq3215, 2022 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36103513
13.
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.
Nat Neurosci
; 25(2): 226-237, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115730
14.
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Acta Neuropathol Commun
; 9(1): 45, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741069
15.
Nuclei Isolation and Super-Resolution Structured Illumination Microscopy for Examining Nucleoporin Alterations in Human Neurodegeneration.
J Vis Exp
; (175)2021 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570098
16.
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei.
Acta Neuropathol Commun
; 9(1): 127, 2021 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34281622
17.
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.
Sci Transl Med
; 13(604)2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34321318
18.
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.
Cell Rep
; 34(13): 108925, 2021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33789100
19.
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
Sci Transl Med
; 13(617): eabd5991, 2021 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705518
20.
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.
iScience
; 24(11): 103221, 2021 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34746695