Detalhe da pesquisa
1.
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.
Nat Immunol
; 21(1): 86-100, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31844327
2.
An essential role for the Zn2+ transporter ZIP7 in B cell development.
Nat Immunol
; 20(3): 350-361, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718914
3.
Themis2 lowers the threshold for B cell activation during positive selection.
Nat Immunol
; 18(2): 205-213, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992403
4.
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.
J Immunol
; 210(5): 547-557, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36637239
5.
An ontogenetic switch drives the positive and negative selection of B cells.
Proc Natl Acad Sci U S A
; 117(7): 3718-3727, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32019891
6.
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Nat Immunol
; 10(8): 831-9, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19597497
7.
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nat Immunol
; 10(12): 1283-91, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19898472
8.
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.
Proc Natl Acad Sci U S A
; 113(26): E3706-15, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27303042
9.
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
PLoS Genet
; 9(1): e1003219, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23382690
10.
DOCK8 is critical for the survival and function of NKT cells.
Blood
; 122(12): 2052-61, 2013 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23929855
11.
Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome.
J Pathol
; 233(1): 18-26, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24293254
12.
DNA repair is limiting for haematopoietic stem cells during ageing.
Nature
; 447(7145): 686-90, 2007 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17554302
13.
DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.
Eur J Immunol
; 41(12): 3423-35, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21969276
14.
NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.
Commun Biol
; 5(1): 1216, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36357486
15.
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Blood
; 113(8): 1805-8, 2009 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18955558
16.
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
J Clin Invest
; 129(9): 3640-3656, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31162141
17.
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
PLoS Med
; 5(3): e54, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18318598
18.
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.
J Clin Invest
; 119(6): 1696-705, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19451691
19.
MyD88-dependent autoimmune disease in Lyn-deficient mice.
Eur J Immunol
; 37(10): 2734-43, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17853409
20.
Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.
J Immunol
; 178(5): 2916-22, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17312136