Detalhe da pesquisa
1.
Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Bioorg Med Chem Lett
; 100: 129630, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38307441
2.
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i).
J Med Chem
; 64(14): 10230-10245, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228444
3.
Discovery of a novel series of CXCR3 antagonists.
Bioorg Med Chem Lett
; 20(12): 3614-7, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20483605
4.
Discovery of a novel series of potent S1P1 agonists.
Bioorg Med Chem Lett
; 20(5): 1516-9, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149651
5.
Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Cancer Immunol Res
; 8(1): 32-45, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31806638
6.
Microwave-assisted ester formation using O-alkylisoureas: a convenient method for the synthesis of esters with inversion of configuration.
J Org Chem
; 74(13): 4753-62, 2009 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19462991
7.
Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.
J Med Chem
; 51(7): 2227-43, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18318469
8.
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Mol Cancer Ther
; 17(12): 2530-2542, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232146
9.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
J Med Chem
; 60(23): 9617-9629, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29111717
10.
Synthesis of 5-carboxamide-oxazolines with a Passerini-Zhu/Staudinger-Aza-Wittig two-step protocol.
J Comb Chem
; 12(5): 613-6, 2010 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20831261
11.
Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
ChemMedChem
; 10(4): 688-714, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25735812
12.
Polymer-supported Mukaiyama reagent: a useful coupling reagent for the synthesis of esters and amides.
Org Lett
; 6(24): 4579-82, 2004 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15548080
13.
Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids.
Org Lett
; 4(6): 1035-7, 2002 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11893215
14.
Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas.
Org Lett
; 4(17): 2961-3, 2002 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12182599
15.
Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids.
Org Lett
; 5(6): 853-6, 2003 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12633089
16.
A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.
Chem Commun (Camb)
; (2): 260-1, 2003 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12585420
17.
Novel application of α-azido aldehydes in multicomponent reactions: synthesis of triazolo-fused dihydrooxazinones via a Passerini reaction-dipolar cycloaddition strategy.
ACS Comb Sci
; 13(5): 453-7, 2011 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21627306
18.
Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.
ACS Med Chem Lett
; 2(8): 644-9, 2011 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900359
19.
Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.
ACS Med Chem Lett
; 2(12): 938-42, 2011 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900284
20.
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.
J Med Chem
; 54(20): 7299-317, 2011 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21916510