Low back pain in eight areas of Britain.

STUDY OBJECTIVE: The aim was to assess the geographical variation in low back pain and associated disability in Britain. DESIGN: This was a cross sectional survey with information collected by postal questionnaire. SETTING: General practices in seven British towns and one rural district. SUBJECTS: 1172 men and 1495 women aged 20-59 years were selected from the age-sex registers of 136 general practitioners in the study areas. MAIN RESULTS: The overall lifetime and one year period prevalences of low back pain were 58.3% and 36.1%. Rates in men and women were similar. Symptoms were more common in men with manual occupations than in those with non-manual jobs, but in women there was no clear trend in relation to social class. Geographical differences in prevalence were small, but the threshold for consulting general practitioners about symptoms varied markedly from place to place. After allowance for age, sex, social class, and severity of symptoms, subjects in the northern towns of Arbroath and Peterlee who had suffered from low back pain in the past year were three to four times as likely to have consulted their doctor about the problem as those living in the southern towns of St Austell and Dorking. Consultation rates in the Midlands were intermediate. CONCLUSIONS: Geographical variation in rates of general practice consultation for low back pain in Britain is due largely to differences in patient behaviour once symptoms have developed. The distribution of important causes of low back back pain across the country is probably fairly uniform.

Risk of low back pain in people admitted to hospital for traffic accidents and falls.

STUDY OBJECTIVE: The aim was to assess the risk of back symptoms in people admitted to hospital because of traffic accidents and falls. DESIGN: The study was a cross sectional survey with information collected by postal questionnaire. Main outcome measures were associations between hospital admission for a traffic accident or fall and reported first onset of back symptoms at the same age and at later ages. SETTING: General practices in seven towns and one rural district. SUBJECTS: 1172 men and 1495 women aged 20-59 years were selected from the age-sex registers of 136 general practitioners in the study areas. MAIN RESULTS: Low back pain was reported by 1556 subjects and hospital admission for a traffic accident or fall by 362. The incidence of low back pain was unusually high during the year of age at which subjects were first admitted to hospital for trauma (RR = 5.5, 95% CI 3.8-7.8). The risk of first developing symptoms in subsequent years was lower, but still significantly increased (RR = 1.3, 95% CI 1.1-1.6). Low back pain which started at the age of an accident tended to last longer than that occurring in other circumstances, and was more often ascribed to injury (56% of cases). However, this proportion was smaller than the calculated attributable proportion for traffic accidents and falls (82%). CONCLUSIONS: The data suggest that a person under age 60 years who is admitted to hospital for a traffic accident or fall has a 7% chance of developing low back pain as result of the injury. However, the link between the injury and subsequent symptoms is often not obvious to the patient.

Housing and appendicitis in Anglesey.

STUDY OBJECTIVE: The aim was to test the hypothesis that provision of household amenities such as domestic hot water systems and bathrooms changed hygiene which thereby triggered the epidemic of appendicitis in Anglesey after the second world war. DESIGN: The study was a cross sectional survey with histories of housing and appendicectomy obtained from Anglesey residents by postal questionnaire. The main outcome measure was reported appendicectomy. SETTING: Four general practices in Anglesey. SUBJECTS: 2531 men and women born during 1923-62 and randomly selected from age-sex registers. Overall response rate was 73.7%. MAIN RESULTS: Subjects born into households with amenities--piped water, hot water systems, and bathrooms had, if anything, a reduced risk of appendicectomy. However, those who subsequently moved to houses that lacked amenities were at significantly higher risk than people born into houses without amenities who later acquired them. CONCLUSIONS: Provision of household amenities was not the important trigger to the epidemic of appendicitis which occurred in Anglesey after the second world war. Rather, the trigger may have been reduction in domestic crowding caused by the falling birth rate. Findings among those who moved house support other evidence that after infancy household amenities protect against appendicitis and contributed to the fall in appendicitis rates in Anglesey after 1965.

Education, reading, and familial tendency as risk factors for myopia in Hong Kong fishermen.

STUDY OBJECTIVE: The aim was to assess the influence of childhood reading on the development of myopia after allowance for familial differences in susceptibility. DESIGN: The study was a cross sectional survey. SETTING: Four fishing harbours in Hong Kong in 1989. SUBJECTS: Participants were 408 men and women aged 15-39 years old from 159 families. MAIN RESULTS: Histories of school attendance and reading habits in childhood were obtained at interview. Myopia was assessed by retinoscopy. Associations between myopia (defined as a refractive error of at least -1.0D in one or both eyes) and indices of reading in childhood were explored. Myopia was more common in subjects who had attended school (odds ratio = 1.7, 95% CI 1.0-3.0), with the highest risks in those who had started school at the earliest ages and who had spent the most time reading and writing while at primary school. Allowance for familial tendency to myopia produced no diminution in the risks associated with reading. CONCLUSIONS: These data support the hypothesis that reading in childhood is a cause of short sight.

Interaction of height and mechanical loading of the spine in the development of low-back pain.

The relation of low-back pain to height and physical activity was examined among 2667 British men and women aged 20-59 years and selected from the general population. Information about occupational activities, height, and lifetime history of low-back pain was obtained from a postal questionnaire. The lifetime prevalence of low-back pain was 58.3%. After allowance for other occupational activities, the onset of low-back pain was strongly associated with heavy lifting at work (men: relative risk (RR) 2.0, 95% confidence interval (95% CI) 1.4-2.8; women: RR 2.2, 95% CI 1.3-3.5). For the men there was also an association with digging (RR 1.6, 95% CI 1.1-2.3). Risk of low-back pain increased with height among the men but not among the women. The risks associated with heavy lifting and digging were greater for the short than for the tall men. Thus the data provide no justification for excluding tall men from heavy manual tasks, despite their greater susceptibility to back problems.

Osteoarthritis of the hip: an occupational disease in farmers.

OBJECTIVE: To test the hypothesis that farmers are at high risk of hip osteoarthritis and to investigate possible causes for such a hazard. DESIGN: Cross sectional survey. SETTING: Five rural general practices. SUBJECTS: 167 male farmers aged 60-76 and 83 controls from mainly sedentary jobs. All those without previous hip replacement underwent radiography of the hip. MAIN OUTCOME MEASURES: Hip replacement for osteoarthritis or radiological evidence of hip osteoarthritis. RESULTS: Prevalence of hip osteoarthritis was higher in farmers than controls and especially in those who had farmed for over 10 years (odds ratio 9.3, 95% confidence interval 1.9 to 44.5). The excess could not be attributed to any one type of farming, and heavy lifting seems the likely explanation. CONCLUSIONS: Manual handling in agriculture should be limited where possible. Consideration should be given to making hip osteoarthritis a prescribed industrial disease in farmers. There may be wider implications for the prevention of hip osteoarthritis in the general population.

Life events and breast cancer prognosis.

OBJECTIVE: To determine whether psychosocial stress, in the form of adverse life events and social difficulties, depressive illness, or lack of confiding relationships, shortens the postoperative disease free interval in breast cancer patients. DESIGN: Prospective follow up of a cohort of newly diagnosed breast cancer patients for 42 months after primary surgical treatment, using a life events and social difficulties schedule (LEDS) and assessment of depressive symptomatology (DSM-III). SETTING: Patients recruited from breast clinics in Southampton and Portsmouth were interviewed in their homes. PATIENTS: 204 women (83% of 246 consecutive cases) treated either by mastectomy or wide excision followed by radiotherapy interviewed four, 24, and 42 months after operation. MAIN OUTCOME MEASURES: Hazard ratios for relapse of breast cancer in relation to various measures of psychosocial stress. Relapse was defined as local recurrence or distant metastasis, or both, with histological or radiological confirmation and timed from the month when clinical symptoms began. RESULTS: After adjustment for age and axillary lymph node involvement, the hazard ratio associated with severe life events or social difficulties (excluding "own health" ones), or both, during the year before breast cancer surgery was 0.43 (95% confidence interval 0.20 to 0.93); for those during the follow up period it was 0.88 (0.48 to 1.64). For prolonged major depression before surgery and during the follow up period, hazard ratios were 1.26 (0.49 to 3.26) and 0.85 (0.41 to 1.79) respectively. For absence of a full confidant the figures were 0.93 (0.42 to 2.09) and 0.86 (0.38 to 1.93). CONCLUSION: These results give no support to the theory that psychosocial stress contributes to relapse of breast cancer.

Estimating the probability of spontaneous delivery conditional on time spent in the second stage.

The duration of second stage labour was studied, retrospectively, among 410 primigravidas who received epidural analgesia in the first stage of spontaneous labour at term (greater than 37 weeks). Survival analysis was used to investigate how the likelihood of a spontaneous delivery was related to time spent in the second stage, and how some maternal and fetal factors influenced this relationship. The proportion of spontaneous deliveries that had occurred by any given time was greatly influenced by maternal age and infant birthweight. However, the women who were least likely to have been delivered by any given time after full dilatation, were also the ones who were least likely to be delivered within any given subsequent time interval. If delivery had not occurred by 3 h, the probability that it would take place in the next 3 h was well under 30% in most cases. We conclude that second stage labour in excess of 3 h is likely to be beneficial only if certain criteria, which are defined in the paper, are met.

Symptomatic Epstein-Barr virus infection and multiple sclerosis.

In a case-control study of 214 patients with multiple sclerosis, recall of infectious mononucleosis in subjects seropositive for Epstein-Barr viral capsid antigen was associated with a relative risk of 2.9 (95% CI 1.1 to 7.2). Those who reported having infectious mononucleosis before the age of 18 years had a relative risk of multiple sclerosis of 7.9 (95% CI 1.7 to 37.9). The pathogenesis of multiple sclerosis may involve an age-dependent host response to Epstein-Barr virus infection.

Increased risk of colorectal cancer associated with congenital anomalies of the urinary tract.

Two young mothers of children presenting with congenital anomalies of the urinary tract underwent colectomy for carcinoma or adenomatosis of the colon. In another family with urinary anomalies, the maternal grandmother had died from carcinoma of the colon at 36 years of age. This previously unreported associated led to two reviews. In the first, of 14 patients with colorectal cancer presenting under 45 years of age, three had known congenital urinary tract anomalies. In the second, which included the first three families, a detailed family history was obtained from children receiving treatment for congenital anomalies of the urinary tract. Seven of 116 grandparents and two mothers among 58 parents had colorectal carcinoma or adenomatosis of the colon; this was significantly greater than the expected incidence. A family history of congenital anomalies of the urinary tract may be a useful marker in screening for colorectal cancer.