Detalhe da pesquisa
1.
Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem Lett
; 25(22): 5402-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403928
2.
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
J Lipid Res
; 52(1): 78-86, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20959675
3.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
J Biol Chem
; 285(17): 12882-91, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172854
4.
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Bioorg Med Chem Lett
; 19(12): 3238-42, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19423344
5.
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
J Biol Chem
; 284(2): 1313-23, 2009 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001363
6.
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
J Lipid Res
; 49(6): 1333-43, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18354137
7.
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation.
J Biol Chem
; 282(28): 20502-12, 2007 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17493938
8.
p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
Bioorg Med Chem Lett
; 16(1): 64-8, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16242322
9.
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.
Bioorg Med Chem Lett
; 12(8): 1219-23, 2002 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11934592