The role of the erythrocyte in the outcome of pregnancy with preeclampsia.

The objective of this study was to analyze the relationships of osmotic and mechanical stability of erythrocytes with anthropometric, biochemical, hematologic and hemodynamic variables in pregnant women with preeclampsia (PE). The studied population consisted of 20 normotensive patients and 16 patients with PE. Patients with PE presented worse gestational outcome, greater hematologic impairment, erythrocytes osmotically more stable in vitro, but in conditions of isotonicity with the in vivo medium, in addition to hyperflow in orbital territory, when compared to normotensive patients. The correlation analysis between anthropometric, hematologic and hemodynamic variables in patients with PE indicated that erythrocytes with lower volumes and lower levels of hemoglobin favor the occurrence of a better gestational outcome, because they are more stable and because they are associated with a decrease in the hemodynamic changes present in the disease. This should mean that the tendency to microcytosis, probably due to a mechanism of compensatory mechanical selection, is a desirable characteristic in the disease.

Efeitos do treinamento resistido sobre indicadores de saúde de sobreviventes de câncer de mama / Effects of resistance training on health indicators in breast cancer survivors

O objetivo deste estudo foi investigar os efeitos do treinamento resistido sobre indicadores de saúde em sobreviventes de câncer de mama. Vinte e duas mulheres com histórico de mastectomia e linfadenectomia completaram 12 semanas de treinamento. Avaliações de força, índice de massa corporal, composição corporal, aspectos hematológicos, bioquímicos e de estabilidade de membrana eritrocitária foram realizadas antes e depois do período de treinamento. Em todos os exercícios, ocorreram ganhos significantes de força máxima e resistência de força. Além disso, houve diminuição do percentual de gordura corporal, aumento do percentual de massa magra, redução de eritrócitos, plaquetas e hemoglobina, bem como mudanças desejáveis para todas as variáveis de perfil lipídico. Em conjunto, esses achados destacam o impacto multidimensional do treinamento resistido sobre a saúde de sobreviventes de câncer de mama e revelam a necessidade de monitoramento constante desse público.

The present study aimed to investigate the effects of resistance training on health indicators in breast cancer survivors. Twenty-two women with a history of mastectomy and lymphadenectomy completed 12 weeks of training. Strength, body mass index, body composition, hematological, and biochemical aspects, and erythrocyte membrane stability were performed before and after the training. In all exercises, there were significant gains in maximal force and force endurance. Moreover, there was a decrease in body fat percentage, an increase in lean mass percentage, a reduction in erythrocytes, platelets, and hemoglobin, as well as desirable changes for all lipid profile variables. Altogether, these findings highlight the multidimensional impact of resistance training on the health of breast cancer survivors and reveal the need for constant monitoring of this public.

Correlations of the glycemic variability with oxidative stress and erythrocytes membrane stability in patients with type 1 diabetes under intensive treatment.

OBJECTIVES: This study aimed to evaluate the correlations of glycemic variability with erythrocyte membrane stability parameters and oxidative stress markers in patients with type 1 diabetes mellitus (T1DM) under intensive treatment. MATERIAL AND METHODS: 90 patients with T1DM and under intensive treatment of the disease were evaluated in relation to anthropometric indices, records of glycemic averages and parameters of glycemic variability, biochemical dosages (glucose, uric acid, lipidogram, glycated hemoglobin, microalbuminuria, creatinine and iron) reticulocyte count, erythrocyte membrane stability parameters and oxidative stress markers (thiobarbituric acid reactive substances, TBARS, and glutathione reductase, GR). RESULTS: Indicators of glycemic variability in the short and long term showed correlations with parameters of membrane stability and markers of oxidative stress (GR). In addition, the comparison of these same parameters between the subgroups consisting of quartiles of GV or glycemic control also showed significant differences. CONCLUSION: In the T1DM patients studied here, glycemic variability showed correlations with oxidative stress and erythrocyte membrane stability variables. This corroborates the hypothesis that glycemic fluctuations interfere with lipid peroxidation and cell membrane behavior, emphasizing its participation in mechanisms related to the development of chronic complications of diabetes.

Effects of combined and resistance training on the inflammatory profile in breast cancer survivors: A systematic review.

OBJECTIVE: The present systematic review aimed to verify the effect of resistance and combined training on the inflammatory profile of breast cancer survivors. DESIGN: The searches were made on the platforms PsycINFO, PubMed, Cochrane, Science Direct and Scopus, from 1996 to 2017, using the keywords: cancer survivors, cancer treatment, cancer patients, breast cancer, inflammation, inflammatory profile, immune function, resistance training, strength training, weight training, physical activity, concurrent training and combined training. References of selected articles were also considered. Seven studies fulfilled the criteria adopted for analysis. RESULTS: None of these studies have shown reduced inflammatory markers in breast cancer survivors undergoing combined or isolated resistance training. CONCLUSIONS: It is not yet possible to conclude which resistance and/or combination training protocol is capable of improving the short-term inflammatory profile in this population. Future studies should seek to establish how structural training variables (intensity, volume, density, intra- and inter-series recovery, among others) act on anti-inflammatory processes in breast cancer survivors.

Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers.

This study aimed to evaluate the influence of acute and chronic exercise on erythrocyte membrane stability and various blood indices in a population consisting of five national-level male swimmers, over 18 weeks of training. The evaluations were made at the beginning and end of the 1st, 7th, 13th and 18th weeks, when volume and training intensity have changed. The effects manifested at the beginning of those weeks were considered due to chronic adaptations, while the effects observed at the end of the weeks were considered due to acute manifestations of the exercise load of that week. Acute changes resulting from the exercise comprised increases in creatine kinase activity (CK) and leukocyte count (Leu), and decrease in hematocrit (Ht) and mean corpuscular volume (MCV), at the end of the first week; increase in the activities of CK and lactate dehydrogenase (LDH), in the uric acid (UA) concentration and Leu count, at the end of the seventh week; increases in CK and LDH activities and in the mean corpuscular hemoglobin concentration (MCHC), at the end of the 13th week; and decrease in the value of the osmotic stability index 1/H50 and increases in the CK activity and platelets (Plt) count, at the end of the 18th week. Chronic changes due to training comprised increase in the values of 1/H50, CK, LDH, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum iron (Fe), MCV and Plt. Although acute training has resulted in decrease in the osmotic stability of erythrocytes, possibly associated with exacerbation of the oxidative processes during intense exercise, chronic training over 18 weeks resulted in increased osmotic stability of erythrocytes, possibly by modulation in the membrane cholesterol content by low and high density lipoproteins.

Geographic distribution of Research Groups and their publications on diet and exercise interventions in cancer in the Brazilian territory

Aims: This study promoted a screening of the geographical distribution and scientific production of the Brazilian research groups on interventions with diet and/or exercise in cancer. Methods: A systematic search on the current basis of the Directory of Research Groups of the National Council for Scientific and Technological Development was done to collect information such as name of group; name of leader; unit of federation; institution; year of creation; number of researchers, students and technicians; and the group's knowledge sub-area. All leaders' curricula were accessed to screen their general publications on cancer and their specific publications on nutrition, exercise and cancer. The publications were classified according to the QUALIS (2015) criteria of the Coordination of Improvement of Higher Education Personnel in the Physical Education area. Results: The Southeast has the highest number of active groups, but the North has no registered groups. The Midwest concentrates the largest number of members in its research groups and the largest overall scientific production on cancer, but the Southeast presents the largest specific production on nutrition, physical exercise and cancer. Most of the specific publications were B2. Conclusion: Research groups and scientific contributions involving this knowledge field need to be encouraged and better distributed geographically throughout the Brazilian territory.(AU)