Detalhe da pesquisa
1.
Small-molecule agents for the treatment of inflammatory bowel disease.
Bioorg Med Chem Lett
; 29(16): 2034-2041, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266686
2.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675441
3.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett
; 25(6): 1333-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701252
4.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Nat Chem Biol
; 7(1): 41-50, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113169
5.
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Drug Metab Dispos
; 39(10): 1840-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742900
6.
Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis.
BMC Rheumatol
; 5(1): 15, 2021 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33781343
7.
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
ACS Med Chem Lett
; 11(4): 506-513, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292557
8.
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
ACS Med Chem Lett
; 11(3): 358-364, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184970
9.
Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.
Bioorg Med Chem Lett
; 19(24): 6991-5, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879134
10.
Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis.
Thromb Res
; 170: 109-118, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30172129
11.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett
; 8(6): 608-613, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626519
12.
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
JCI Insight
; 2(7): e90111, 2017 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28405610
13.
A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.
Oncotarget
; 5(4): 908-15, 2014 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24659719
14.
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
J Med Chem
; 57(9): 3856-73, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24779514