Detalhe da pesquisa
1.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200244
2.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200252
3.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200249
4.
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett
; 12(7): 1143-1150, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267885
5.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214829
6.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem
; 62(5): 2265-2285, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30785748
7.
Identification of potent tricyclic prodrug S1P1 receptor modulators.
Medchemcomm
; 8(4): 725-729, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108791
8.
Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2.
J Med Chem
; 49(13): 3766-9, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789733
9.
Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.
Bioanalysis
; 8(4): 265-74, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26807991
10.
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.
ACS Med Chem Lett
; 7(3): 283-8, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985316
11.
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.
J Med Chem
; 59(21): 9837-9854, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27726358
12.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem
; 59(19): 9173-9200, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27583770
13.
Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.
Bioanalysis
; 6(13): 1795-811, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157486
14.
Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.
Bioanalysis
; 4(1): 29-40, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22191592
15.
A bioanalytical strategy utilizing dried blood spot sampling and LC-MS/MS in discovery toxicology studies.
Bioanalysis
; 4(9): 1057-64, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22612686
16.
What is next for dried blood spots?
Bioanalysis
; 4(16): 2059-65, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22946921
17.
Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS.
Bioanalysis
; 4(5): 511-28, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22409550
18.
DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors.
Bioanalysis
; 2(8): 1415-22, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21083342
19.
Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
J Pharm Sci
; 99(4): 2135-52, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19780144
20.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
J Med Chem
; 52(23): 7778-87, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19769332