Detalhe da pesquisa
1.
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.
PLoS Pathog
; 17(7): e1009734, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34310651
2.
Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.
Parasitol Res
; 122(12): 2751-2772, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37851179
3.
Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis.
Int J Mol Sci
; 24(4)2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36834557
4.
Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter.
Mol Microbiol
; 116(6): 1489-1511, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34738285
5.
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.
Mol Microbiol
; 116(2): 564-588, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932053
6.
Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals.
Int J Mol Sci
; 23(5)2022 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35269985
7.
Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters.
Int J Mol Sci
; 23(15)2022 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897714
8.
A Toxoplasma gondii Oxopurine Transporter Binds Nucleobases and Nucleosides Using Different Binding Modes.
Int J Mol Sci
; 23(2)2022 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35054895
9.
The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes.
Molecules
; 27(5)2022 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35268726
10.
The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
Molecules
; 27(22)2022 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36432150
11.
Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches.
Molecules
; 27(22)2022 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36432189
12.
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.
J Biol Chem
; 295(24): 8331-8347, 2020 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32354742
13.
Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids.
Antimicrob Agents Chemother
; 65(3)2021 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33361300
14.
Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana.
Molecules
; 26(13)2021 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206940
15.
Purine and pyrimidine transporters of pathogenic protozoa - conduits for therapeutic agents.
Med Res Rev
; 40(5): 1679-1714, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144812
16.
Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32601163
17.
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
J Antimicrob Chemother
; 75(4): 958-967, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860098
18.
The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo.
Exp Parasitol
; 208: 107793, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31711973
19.
The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.
Molecules
; 25(21)2020 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33167520
20.
Alternative oxidase inhibitors: Mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi.
Med Res Rev
; 39(5): 1553-1602, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30693533