Detalhe da pesquisa
1.
(R)-α-Trifluoromethylalanine as a 19 F NMR Probe for the Monitoring of Protease Digestion of Peptides.
Chembiochem
; 23(1): e202100470, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34738292
2.
Hydrogen Bond Acceptor Propensity of Different Fluorine Atom Types: An Analysis of Experimentally and Computationally Derived Parameters.
Chemistry
; 27(34): 8764-8773, 2021 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33949737
3.
Fluorine NMR functional screening: from purified enzymes to human intact living cells.
J Biomol NMR
; 74(10-11): 613-631, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32347447
4.
19 F NMR transverse and longitudinal relaxation filter experiments for screening: a theoretical and experimental analysis.
Magn Reson Chem
; 55(2): 106-114, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27514284
5.
19 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.
Magn Reson Chem
; 55(12): 1091-1095, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28762528
6.
Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.
Chemistry
; 22(22): 7592-601, 2016 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27112430
7.
Fluorine nuclear magnetic resonance-based assay in living mammalian cells.
Anal Biochem
; 495: 52-9, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26686030
8.
Fluorine as a hydrogen-bond acceptor: experimental evidence and computational calculations.
Chemistry
; 20(35): 11058-68, 2014 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044441
9.
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
Bioorg Med Chem
; 22(15): 4135-50, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24980703
10.
Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.
Chembiochem
; 14(13): 1611-9, 2013 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23918626
11.
Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them.
Prog Nucl Magn Reson Spectrosc
; 138-139: 52-69, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38065668
12.
Technical and practical aspects of (19) F NMR-based screening: toward sensitive high-throughput screening with rapid deconvolution.
Magn Reson Chem
; 50(9): 592-7, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22821476
13.
Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts.
ChemMedChem
; 17(13): e202200163, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35475323
14.
Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening.
Magn Reson Chem
; 49(4): 199-202, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21387401
15.
Perspectives on NMR in drug discovery: a technique comes of age.
Nat Rev Drug Discov
; 7(9): 738-45, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19172689
16.
Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.
Proteins
; 78(16): 3281-91, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20886466
17.
Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.
J Am Chem Soc
; 131(36): 12949-59, 2009 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19702332
18.
Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects.
J Med Chem
; 62(5): 2218-2244, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30295487
19.
Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor.
ChemMedChem
; 14(11): 1115-1127, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30925009
20.
A Ligand-Based NMR Screening Approach for the Identification and Characterization of Inhibitors and Promoters of Amyloid Peptide Aggregation.
ChemMedChem
; 12(17): 1458-1463, 2017 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28722296