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1.
JDR Clin Trans Res ; 9(2): 123-139, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37593882

RESUMO

OBJECTIVE: This study completed the development of a standardized patient-centered dental home (PCDH) framework to align and integrate with the patient-centered medical home. This study identified measure concepts and specific measures and standards to complete the 4-level measurement framework to implement and evaluate a PCDH. This study built on prior model development, which identified the PCDH definition and characteristics and the components nested within those characteristics. METHODS: An environmental scan identified existing oral health care quality measure concepts, measures, and standards for rating by the project's National Advisory Committee (NAC). A modified Delphi process, adapted from the RAND appropriateness method, was used to obtain structured feedback from the NAC. NAC members rated measure concepts on importance and, subsequently, specific measures and standards on feasibility, validity, and actionability using a 1 to 9 rating scale. Criteria for model inclusion were based on median ratings and rating dispersion. Open-ended comments were elicited to inform model inclusion as well as identify additional concepts. RESULTS: We identified more than 500 existing oral health care measures and standards. A structured process was used to identify a subset that best aligned with a PCDH for rating by the NAC. Four Delphi rounds were completed, with 2 rounds to rate measure concepts and 2 rounds to rate measures and standards. NAC quantitative ratings and qualitative comments resulted in a total of 61 measure concepts and 47 measures and standards retained for inclusion in the framework. CONCLUSIONS: The NAC ratings of measure concepts, and specific measures and standards nested within those concepts, completed the 4-level PCDH measurement framework. The resulting framework allows for the development and implementation of core measure sets to identify and evaluate a PCDH, facilitating quality improvement and dental-medical integration. KNOWLEDGE TRANSFER STATEMENT: Clinicians, payers, health care systems, and policy makers can use the results of this study to guide and assess implementation of the various components of a patient-centered dental home and to support dental-medical integration.


Assuntos
Melhoria de Qualidade , Qualidade da Assistência à Saúde , Humanos , Assistência Centrada no Paciente , Técnica Delphi
2.
Eur J Dent Educ ; 17(4): 218-24, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24127762

RESUMO

OBJECTIVE: This study evaluated medical interns' oral health knowledge, and other factors influencing their ability and willingness to perform oral-health-related practices for high-caries-risk children. METHODS: A 15-item survey was emailed to all eligible graduating fifth-year medical students at King Khalid University Hospital to address these areas of interest. Chi-square statistics and logistic regression models were used to analyse data. RESULTS: One-hundred and twenty-one (49%) usable surveys were returned from two mailings. On questions regarding comfort levels when performing oral-health-related practices on children under age 3, physicians noted high levels of comfort with all specified oral health practices. Regarding satisfaction of students with medical training, the majority of respondents (87.5%) rated their medical training as fair or poor in preparing them for oral health assessments compared to only 35%, 29% and 7% of respondents giving fair or poor ratings to child abuse identification, caring for special needs patients and primary care paediatric practice, respectively. Additionally, although 90% of respondents noted that the role of primary physicians in counselling/referring children with oral health was important, 60% did not agree with the AAPD and AAP guidelines that state that all children should be referred to a dentist by 12 months of age. Multivariate logistic regression analyses revealed several statistically significant variables that predict the likelihood of performing various oral-health-related practices. The choice of public-health-oriented future clinical goals, the level of oral health knowledge, how interns rated their oral health training in medical school and the average number of children seen per week, all--to varying degrees--proved important predicator variables for the likelihood of performing them once in practice. CONCLUSIONS: More oral-health-related training of medical students seems warranted and could improve their interest in providing oral-health-related screening and referrals in practice. Increasing student exposure to child patients and increasing exposures to oral health knowledge and problems could be targeted towards students interested in primary care and public health to use resources most efficiently in the effort to combat the growing caries levels amongst young children in Saudi Arabia.


Assuntos
Assistência Odontológica para Crianças , Conhecimentos, Atitudes e Prática em Saúde , Saúde Bucal/educação , Estudantes de Medicina/psicologia , Criança , Pré-Escolar , Feminino , Humanos , Internato e Residência , Masculino , Arábia Saudita , Inquéritos e Questionários
3.
JDR Clin Trans Res ; 8(4): 367-373, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-35708460

RESUMO

INTRODUCTION: Strong evidence supports use of dental sealants to prevent tooth decay, and professional guidelines recommend use in children with elevated caries risk. However, not all children indicated for sealants receive this preventive intervention, even when they use routine dental care. OBJECTIVE: The aim of this study was to explore the extent to which dentists' use of sealants varied in pediatric patients with elevated caries risk. METHODS: Claims and enrollment data from a private dental program were used to identify a cohort of 6- to 17-y-olds with elevated caries risk (N = 27,677) and general dentists (N = 818) who provided services to the children. Children were identified as having elevated caries risk based on history of restorative treatment over a 5-y period (2010-2014). The 2 outcomes of interest were whether a dentist provided any sealants to children with elevated risk and, if so, the extent to which these were used during a 2-y observation period (2013-2014). A 2-stage hurdle model was used for multivariable analysis to identify dentist characteristics associated with sealant use. RESULTS: Over the observation period, 13.3% (n = 109) of dentists did not provide any sealants to their elevated risk patients from the study cohort. Logistic regression found that female dentists were significantly more likely to have used sealants (odds ratio = 2.27); dentist age and practice in an isolated small rural town were negatively associated with any sealant use. However, among dentists who did place sealants (n = 709), female dentists, older dentists, dentists in solo practice, and those working full-time were significantly more likely to provide sealants to a child. Overall, substantial variation in practitioners' use of sealants was observed. CONCLUSION: This is the first study to explore provider-level variation in sealant use, representing a critical step in future efforts to increase routine use of sealants by dentists and eliminate oral health disparities. KNOWLEDGE TRANSFER STATEMENT: Findings from this study can be used to design targeted policy and behavioral interventions to increase sealant use by general dentists. This study provides foundational evidence for future research that explores motivation and barriers to routine use of preventive dental interventions by clinicians.


Assuntos
Suscetibilidade à Cárie Dentária , Cárie Dentária , Humanos , Criança , Feminino , Selantes de Fossas e Fissuras/uso terapêutico , Cárie Dentária/epidemiologia , Cárie Dentária/prevenção & controle , Modelos Logísticos , Odontólogos
4.
Oral Dis ; 18(1): 74-84, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21883709

RESUMO

OBJECTIVES: This study examined the behavioral health of young children with oral clefts, and effects of satisfaction with facial appearance, cleft team care, number of cleft-related surgeries, and socioeconomic status (SES). SUBJECTS AND METHODS: The study included a population-based sample of 104 children aged 2-12 years with isolated oral clefts from the state of Iowa. Behavior was evaluated with the Child Behavior Checklist or the Pediatric Behavior Scale 30, depending on age, compared with normative samples. RESULTS: Risks of behavioral problems were not significantly different from normative samples except for higher inattention/hyperactivity risks at age 6-12 years. Low satisfaction with facial appearance was associated with behavioral problems in all domains, except aggression. Team-care effects were not associated with behavioral problems. Number of cleft-related surgeries was associated with increased anxiety/depression and somatic symptom risks. Higher SES was associated with reduced inattention/hyperactivity, aggressive/oppositional behavior, and somatic symptoms. CONCLUSIONS: Most children with oral clefts may have similar behavioral health outcomes to unaffected children, except for increased inattention/hyperactivity risks at older ages. However, low satisfaction with facial appearance, increased exposure to surgeries, and lower SES may significantly increase behavioral problems. Also, the findings emphasize the need to study the representation of behavioral health professionals on cleft teams and access to behavioral health care.


Assuntos
Comportamento Infantil , Fenda Labial/psicologia , Fissura Palatina/psicologia , Agressão/psicologia , Ansiedade/etiologia , Transtorno do Deficit de Atenção com Hiperatividade/etiologia , Estudos de Casos e Controles , Criança , Transtornos do Comportamento Infantil/etiologia , Transtornos do Comportamento Infantil/psicologia , Pré-Escolar , Fenda Labial/complicações , Fissura Palatina/complicações , Depressão/etiologia , Humanos , Iowa , Mães , Razão de Chances , Procedimentos Cirúrgicos Bucais/psicologia , Equipe de Assistência ao Paciente , Autoimagem , Classe Social , Distúrbios da Fala/etiologia
5.
JDR Clin Trans Res ; 3(1): 101-108, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-30938652

RESUMO

This study explores how travel distance and other transportation barriers are associated with dental utilization in a Medicaid expansion population. We analyzed data from the Iowa Dental Wellness Plan (DWP), which provides comprehensive dental benefits for low-income adults aged 19 to 64 y as part of Iowa's Medicaid expansion. Transportation and geographical characteristics were evaluated as enabling factors within the framework of Andersen's behavioral model of health services use. In March 2015, a random sample of DWP members ( n = 4,800) was surveyed; adjusted survey response rate was 30% ( n = 1,258).The questionnaire was based on the Consumer Assessment of Healthcare Providers and Systems (CAHPS) Dental Plan Survey and assessed need for dental care, use of dental services and transportation to visits, and self-perceived oral health status. Respondent and dentist addresses were geocoded and used to calculate distance to the nearest DWP general dentist. A logistic regression model predicting utilization of dental care was developed using variables representing each domain of the behavioral model. Most respondents (57%) reported a dental visit since enrolling. Overall, 11% of respondents reported unmet dental need due to transportation problems. Median distance to the nearest general dentist was 1.5 miles. In the adjusted model, travel distance was not significantly associated with the likelihood of dental utilization. However, other transportation-related issues were significantly associated with utilization, including concern about cost of transportation and driver/passenger status. As concern about transportation cost increased, likelihood of having a dental visit decreased. Targeted approaches to assisting low-income populations with transportation barriers should be considered in designing policies and interventions to improve access to dental care. Knowledge Transfer Statement: The results of this study can be used by policy makers and public health planners when designing programs and interventions to improve access to dental care. Consideration of transportation availability and costs could improve utilization of routine dental care, especially among low-income populations.


Assuntos
Assistência Odontológica , Acessibilidade aos Serviços de Saúde , Medicaid , Meios de Transporte , Adulto , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Iowa , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Pobreza , Meios de Transporte/economia , Viagem , Estados Unidos
6.
JDR Clin Trans Res ; 3(1): 91-100, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29276779

RESUMO

The objective of the study was to assess the effects of medical well baby visits in promoting earlier first dental visits. We analyzed Iowa Medicaid claims data (2000-2013). The sample included 4 cohorts of children born in 2000, 2003, 2007, or 2010 and enrolled in Medicaid from birth (N = 38,211). Children were followed for 3 y. The independent variables were cohort year and medical well baby visit frequency during 3 time periods (birth to age 10 mo, ages 11-19 mo, ages 20-36 mo). We used survival analyses to estimate first dental visit rates. First dental visit rates improved significantly from 2000 to 2013, with children in latter cohorts having significantly earlier first dental visits. Children with more medical well baby visits before age 11 mo had significantly delayed first dental visit rates than children with fewer medical well baby visits. The opposite was observed for children with more medical well baby visits between ages 11 to 19 mo and ages 20 to 36 mo. First dental visit rates for Medicaid-enrolled children have improved, but there continues to be a need for early interventions to improve age 1 dental visits and other preventive oral health behaviors. Knowledge Transfer Statement: The results of this study can be used by policy makers when developing strategies to improve access to dental care for young children in Medicaid. With consideration to promoting earlier preventive dental visits for publicly insured children, this study could lead to early interventions and improved health outcomes.

7.
JDR Clin Trans Res ; 1(1): 86-94, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28879239

RESUMO

When traditional ranking and rating surveys are used to assess dentists' treatment decisions, the patient's source of payment appears to be of little importance. Therefore, this study used the marketing research tool conjoint analysis to investigate the relative impact of source of payment along with the child's age and cooperativeness on pediatric dentists' willingness to use Atraumatic Restorative Treatment (ART) to restore posterior primary teeth. A conjoint survey was completed by 707 pediatric dentists. Three factors (age of the child, cooperativeness, type of insurance) were varied across 3 levels to create 9 patient scenarios. The relative weights that dentists placed on these factors in the restorative treatment decision process were determined by conjoint analysis. "Cooperativeness" (52%) was the most important factor, "age of the child" (26%) the second-most important factor, followed by "insurance status of the child" (22%). For the third factor, insurance, pediatric dentists were least willing to use ART with publicly insured children (-0.082), and this was significantly different from their willingness to use ART with uninsured children (0.010) but not significantly different than their willingness to use ART for children with private insurance (0.073). Unlike traditional ranking and rating tools, conjoint analysis found that the insurance status of the patient appeared to be an important factor in dentists' decisions about different restorative treatment options. When pediatric dentists were forced to make tradeoffs among different patients' factors, they were most willing to use ART technique with young, uncooperative patients when they had no insurance. Knowledge Transfer Statement: The present study suggests the feasibility of using techniques borrowed from marketing research, such as conjoint analysis, to understand dentists' restorative treatment decisions. Results of this study demonstrate pediatric dentists' willingness to use a particular restorative treatment option (Atraumatic Restorative Treatment in this application) when forced to make tradeoffs in a "conjoined," or holistic, context among different factors presented in real-life patient scenarios. A deeper understanding of dentists' treatment decisions is vital to develop valid practice guidelines and interventions that encourage the use of appropriate restorative treatment modalities.

8.
Hypertension ; 34(4 Pt 2): 1007-11, 1999 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-10523399

RESUMO

A fructose-enriched diet promotes hypertension in rats. We thought that an enhancement of the glycolytic and/or lipid disorder (s) that raise blood pressure could be the cause. Therefore, we studied 4 groups of Sprague-Dawley rats (+/-200 g): (1) control rats received a standard diet and tap water; (2) the glycerol group of rats received a standard diet and 0.54 mol/L glycerol in tap water; (3) the fructose group was given a fructose-enhanced diet (chow had 55% fructose instead of dextrin) and tap water; and (4) the fructose-glycerol group was given the fructose-enhanced diet and 0. 54 mol/L glycerol in drinking water. At the end of the second week, the findings were as follows. Blood pressure was 149+/-2 mm Hg in the fructose-glycerol group versus 129+/-2 (P<0.001), 131+/-2 (P<0. 001), and 140+/-3 (P<0.005) mm Hg in the control, glycerol, and fructose groups, respectively. Insulinemia was higher in the fructose-glycerol group than the control (P<0.001), glycerol (P<0. 001), and fructose groups (P<0.001); triglyceridemia was higher in the fructose-glycerol (P<0.02), fructose (P<0.05), and glycerol groups (P<0.02) than the control group. Thoracic aorta rings showed a lower ED(50) to 12,13-phorbol dibutyrate in the fructose-glycerol group than in the control (P<0.001), glycerol (P<0.002), and fructose groups (P<0.001). In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group).


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Frutose/administração & dosagem , Glicerol/farmacologia , Hipertensão/induzido quimicamente , Animais , Dieta , Sinergismo Farmacológico , Hipertensão/metabolismo , Hipertensão/fisiopatologia , Insulina/metabolismo , Masculino , Ratos , Ratos Sprague-Dawley
9.
Neurology ; 57(2): 357-9, 2001 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-11468332

RESUMO

The detection of respiratory muscle weakness in ALS is necessary to plan initiation of noninvasive positive pressure ventilation and begin discussion of advanced directives. The authors measured the erect seated and supine forced vital capacity (FVC) in 38 patients with ALS and 15 controls. The supine FVC is significantly lower and the erect--supine FVC difference is significantly greater in patients with complaints of dyspnea, orthopnea, and daytime fatigue.


Assuntos
Esclerose Lateral Amiotrófica/fisiopatologia , Postura/fisiologia , Transtornos Respiratórios/fisiopatologia , Capacidade Vital/fisiologia , Adulto , Feminino , Humanos , Masculino
10.
J Dent Res ; 83(11): 854-8, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15505235

RESUMO

Crowns and large amalgams protect structurally compromised teeth to various degrees in different situations. The aim of this investigation was to evaluate the survival of teeth with these two types of restorations and the factors associated with better outcomes. Retrospective administrative and chart data were used. Survival was defined and modeled as: (1) receipt of no treatment and (2) receipt of no catastrophic treatment over five- and 10-year periods. Analyses included: Kaplan-Meier survival curves, Log-Rank tests, and Cox proportional hazards regression modeling. Crowns survived longer with no treatment and with no catastrophic treatment; however, mandibular large amalgams were least likely to have survived with no treatment, and maxillary large amalgams were least likely to have survived with no catastrophic treatment. Having no adjacent teeth also decreased survival. Crowns survived longer than large amalgams, but factors such as arch type and the presence of adjacent teeth contributed to the survival of large amalgams.


Assuntos
Coroas , Amálgama Dentário , Falha de Restauração Dentária , Restauração Dentária Permanente/métodos , Dente Pré-Molar , Feminino , Humanos , Estudos Longitudinais , Masculino , Dente Molar , Modelos de Riscos Proporcionais , Retratamento , Estudos Retrospectivos , Análise de Sobrevida , Fatores de Tempo
11.
Gen Hosp Psychiatry ; 22(3): 144-52, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10880707

RESUMO

This study evaluated unexplained symptoms in primary care from the perspective of both patients and physicians. The data were obtained from two 1998 statewide surveys, one targeting Medicaid patients and the other all primary care physicians in the state. There were 439 patients who responded (45% response rate) and 280 primary care physicians who responded (33% response rate). Half of the patients and half of the physicians were in non-metropolitan counties. Half of the patients reported unexplained symptom usually or always, and 75% of whom sought help for these symptoms. Fifty-two percent of these patients believed their physician was very concerned about their unexplained symptoms. Eighty percent of them rated their physician as providing the best possible care compared to only 49% of patients whose physician did not care about their unexplained symptoms (P=.001). Among the physicians, only 14% reported very good or excellent satisfaction with managing unexplained symptoms as compared to 44% who claimed similar satisfaction in managing psychological problems. Physicians who saw themselves as more effective in dealing with somatoform symptoms were more likely to be in solo practice (P<.005), or in the same location for at least five years (P=.04). Residence in a nonmetropolitan county did not affect patient reporting of symptoms, patient perception of physician concern about symptoms, or physician satisfaction in managing these symptoms. These results indicate the prevalence and importance of unexplained symptoms in the Medicaid population and the comfort of physicians in managing these symptoms. There is an unmet need among primary care physicians to learn how to manage patients with unexplained symptoms.


Assuntos
Pacientes , Médicos , Atenção Primária à Saúde , Transtornos Somatoformes/diagnóstico , Transtornos Somatoformes/psicologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Satisfação Pessoal , Transtornos Somatoformes/terapia , Inquéritos e Questionários
12.
J Public Health Dent ; 52(2): 52-8, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1564691

RESUMO

Numerous proposals have been suggested for expanding health insurance coverage to the over 30 million Americans without health insurance. These proposals range from establishing a program of national health insurance modeled after the Canadian system to establishing statewide risk pools. Many of these proposals could have an impact on financial access to dental care for the approximately 120 million people without dental insurance. Dental insurance coverage has been shown to increase access to dental services and improve oral health status. Oral health professionals could facilitate discussions concerning health insurance expansion by informing policymakers about important preventive benefits to be gained by improving access to dental services. Dental public health professionals can serve as a bridge between organized dentistry and health policymakers by providing information to help formulate the priorities and characteristics of a dental health insurance program. This visibility and influence in the health policy arena would be beneficial to dentistry and could ultimately result in greater access to dental services and improved oral health for the uninsured.


Assuntos
Serviços de Saúde Bucal , Acessibilidade aos Serviços de Saúde , Seguro Odontológico , Seguro Saúde , Política de Saúde , Estados Unidos
13.
J Public Health Dent ; 60(1): 28-32, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10734613

RESUMO

OBJECTIVE: This paper examines the cost to the Iowa Medicaid program of hospitalizing young children for restorative dental care under general anesthesia, and describes the dental services received in this setting. METHODS: Medicaid dental claims for young children receiving restorative dental care under general anesthesia during fiscal year 1994 were matched with corresponding hospital and anesthesia claims. RESULTS: The total cost to the Medicaid program of treating a child in the hospital under general anesthesia was $2,009 per case. Less than 2 percent of Medicaid-enrolled children under 6 years of age who received any dental service accounted for 25 percent of all dollars spent on dental services for this age group, including hospital and anesthesia care. The most frequent type of procedure was stainless steel crowns (SSCs), with an average of almost six per case. CONCLUSIONS: Early identification, prevention, and intervention are critically important to prevent the costly treatment of children with ECC in hospital operating rooms.


Assuntos
Anestesia Dentária/economia , Anestesia Geral/economia , Assistência Odontológica para Crianças/economia , Restauração Dentária Permanente/economia , Custos de Cuidados de Saúde , Hospitalização/economia , Medicaid/economia , Fatores Etários , Pré-Escolar , Resinas Compostas/economia , Coroas/economia , Amálgama Dentário/economia , Cárie Dentária/economia , Cárie Dentária/terapia , Unidade Hospitalar de Odontologia/economia , Honorários Odontológicos , Humanos , Iowa , Salas Cirúrgicas/economia , Pulpotomia/economia , Extração Dentária/economia , Estados Unidos
14.
J Am Dent Assoc ; 124(5): 113-31, 1993 May.
Artigo em Inglês | MEDLINE | ID: mdl-8482767

RESUMO

Reported inconsistencies in entry level exams and variations in available disciplinary mechanisms suggest the need for modifications to improve these processes. A quality assurance system combining education with some sanctions is likely to engender dentist support and improve quality of care.


Assuntos
Assistência Odontológica/normas , Licenciamento em Odontologia , Revisão por Pares , Garantia da Qualidade dos Cuidados de Saúde/legislação & jurisprudência , Conselhos de Especialidade Profissional , Disciplina no Trabalho , Humanos , Inquéritos e Questionários , Estados Unidos
15.
J Am Dent Assoc ; 123(6): 68-73, 1992 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1619149

RESUMO

This study found significant variation in pass rates within and among state and regional dental board clinical examinations during 1979-1988. This suggests that factors other than the abilities of the candidates influence exam outcomes. As long as individual states can argue that there is currently no definitive system to assure the quality of dental care, states may remain reluctant to relax their restrictions on dentists' freedom of movement.


Assuntos
Licenciamento em Odontologia , Avaliação Educacional/normas , Avaliação Educacional/estatística & dados numéricos , Humanos , Conselhos de Especialidade Profissional/estatística & dados numéricos , Estados Unidos/epidemiologia
16.
Arch Physiol Biochem ; 108(5): 415-21, 2000 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11262599

RESUMO

Nitric oxide (NO) has been identified as an effective vascular relaxant. This study analyses the contribution of the precursor L-arginine (L-arg) by oral administration in two kidney-two clip hypertension in the rat (2K-2C). Two groups were studied: sham (SH, n=21) and hypertensive (HT, n=15). After 4 weeks of surgery, a group of rats remained as controls (SHc and HTc, respectively), while others were supplemented with L-arg (1.25 g/L) in drinking water (SHa and HTa) for 3 weeks. Blood pressure was significantly increased in 2K-2C rats but remained unchanged after L-arg treatment. Plasma nitrite/nitrate concentrations were not different among groups. The contractile response of aorta to KCl, serotonin and the protein kinase C (PKC) stimulant, phorbol 12,13-dibutyrate (PDBu) was also evaluated. Higher contractile responses to PDBu (p<0.001) and lower relaxation to acetylcholine (Ach 10(-6) M, p<0.05 and 10(-5)M, p<0.02) were observed in aortic rings of HTc vs SHc; L-arg supplementation significantly diminished tension development to all agonists (p<0.05) but failed to modify the lower relaxation to Ach in HTa. Thromboxane (TxA(2)) - synthesis in rings of HTc was higher than in SHc under basal conditions (p<0.05). In the groups with supplement of L-arg, PDBu significantly stimulated prostacyclin (PGI(2)) synthesis more in HTa rats than in SHa ones (p<0.05). To conclude: 1) L-arg fails to modify hypertension development in 2K-2C rats; and 2) L-arg exerts a beneficial effect on the vascular wall, by reducing contractility in rings from HTa rats; it also improved PGI(2) synthesis under PDBu stimulation. 3) greater PKC activation and TxA(2) production rather than lower NO availability might result in systemic hypertension in 2K-2C rats.


Assuntos
Administração Oral , Arginina/farmacologia , Rim/efeitos dos fármacos , Acetilcolina/farmacologia , Animais , Arginina/administração & dosagem , Pressão Sanguínea/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Epoprostenol/biossíntese , Epoprostenol/metabolismo , Hipertensão/tratamento farmacológico , Soluções Isotônicas/farmacologia , Masculino , Músculo Liso Vascular/efeitos dos fármacos , Nitratos/sangue , Nitritos/sangue , Tamanho do Órgão/efeitos dos fármacos , Dibutirato de 12,13-Forbol/farmacologia , Cloreto de Potássio/farmacologia , Proteína Quinase C/metabolismo , Ratos , Ratos Sprague-Dawley , Serotonina/farmacologia , Tromboxano B2/biossíntese , Fatores de Tempo
17.
Arch Physiol Biochem ; 109(1): 32-7, 2001 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11471069

RESUMO

Previous studies from our own laboratory have shown that abdominal aorta rings from two kidney - two clip hypertensive rats (HT) develop hypersensitivity to serotonin (SER) which is related to a decreased nitric oxide (NO) availability and enhanced thromboxane A2 production. In the present study we investigated whether calcium and prostanoid-NO interactions are involved in these findings. To this purpose, the aortic responses to SER were analyzed in calcium-free medium and in calcium-depleted aorta placed in normal medium. Moreover, effects of ridogrel (RID, an antagonist of TxA 2/PGH2 receptors and inhibitor of thromboxane synthetase) were analysed by cumulative dose-response curves to SER in the presence and in the absence of the NO synthase inhibitor N(omega)-nitro-L-arginine (NOLA). Vascular responses to SER in vessels from HT rats were associated with increased intracellular calcium mobilization. In addition, hypersensitivity to SER in HT group respect to sham group (SH) disappeared in the presence of RID, NOLA and RID plus NOLA. RID decreases the maximum tension to SER and this effect was prevented by NOLA. This inhibition was of a greater magnitude in rings from sham rats (SH): 34 +/- 6% than in HT rats: 15 +/- 6% (p < 0.05). Besides, RID decreased the sensibility to SER in the presence of NOLA only in the HT group. In conclusion, the present study suggests that SER hypersensitivity observed in HT rats is related to a facilitated intracellular calcium mobilization and enhanced TxA2-endoperoxide response. Changes in membrane SER-gated calcium channels opening are observed only during the early hypertensive period. Besides, the lower depressor effect of RID on the maximal tension to SER in aorta rings from HT rats are related with a decreased NO availability in this model of renovascular hypertension.


Assuntos
Aorta/efeitos dos fármacos , Cálcio/farmacologia , Rim/metabolismo , Serotonina/farmacologia , 6-Cetoprostaglandina F1 alfa/biossíntese , Animais , Pressão Sanguínea/efeitos dos fármacos , Relação Dose-Resposta a Droga , Inibidores Enzimáticos/farmacologia , Sequestradores de Radicais Livres/farmacologia , Hipertensão/tratamento farmacológico , Masculino , Contração Muscular/efeitos dos fármacos , Nitroarginina/farmacologia , Ácidos Pentanoicos/farmacologia , Prostaglandina-Endoperóxido Sintases/metabolismo , Prostaglandinas/farmacologia , Piridinas/farmacologia , Ratos , Ratos Wistar , Tromboxano B2/biossíntese , Fatores de Tempo
18.
Ann Ital Med Int ; 8(4): 224-6, 1993.
Artigo em Italiano | MEDLINE | ID: mdl-8161477

RESUMO

Subjects with thalassemia major frequently have bone disorders of debatable pathogenesis. We attempt here to analyze the relationships between siderosis and thalassemic osteodystrophy by assessing calcium-phosphorus balance, hormone-vitamin homeostasis, osteoblastic-osteoclastic activity parameters, and bone mineral density (BMD) in 30 patients with thalassemia major (16 males, 14 females, age range 17-30 years). We found a significant increase in ferritin (p < 0.001) and significant decreases in serum i-PTH, 25OHD3, 1.25(OH)2D3, osteocalcin, estradiol, testosterone and FT4 (p < 0.001) in both sexes. In all patients a net decrease of bone mineral density was documented (p < 0.001). These results were then submitted to linear regression analysis: positive correlations between BMD and FT3, testosterone, estradiol (p < 0.01), were documented, and an inverse correlation between osteocalcin and ferritin was confirmed. Our findings suggest that thalassemic osteodystrophy is the result of several inhibitory influences on osteoblastic activity and bone apposition (related to hormone deficits and siderosis) which are aggravated further by anemia, chronic hypoxia and red marrow expansion.


Assuntos
Doenças do Desenvolvimento Ósseo/etiologia , Talassemia beta/complicações , Adolescente , Adulto , Densidade Óssea , Doenças do Desenvolvimento Ósseo/epidemiologia , Doenças do Desenvolvimento Ósseo/metabolismo , Feminino , Humanos , Modelos Lineares , Masculino , Siderose/complicações , Siderose/epidemiologia , Siderose/metabolismo , Talassemia beta/epidemiologia , Talassemia beta/metabolismo
19.
Pediatr Dent ; 19(5): 310-4, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9260221

RESUMO

All Medicaid-enrolled children are eligible to receive dental care through the Early and Periodic Screening, Diagnostic and Treatment Program (EPSDT). As part of an evaluation of the effectiveness of the EPSDT program in Iowa, Medicaid enrollment and claims files from fiscal year (FY) 1994 were used to evaluate the utilization of dental services by Medicaid-enrolled children younger than age 6 during FY 1994. During FY 1994, 23% of Medicaid-enrolled children younger than age 6 received at least one dental service while enrolled in the Medicaid program. The total Medicaid-allowed charges for all dental services provided to this population while enrolled in Medicaid during FY 1994 was $1.53 million (the amount Medicaid would pay for the service, prior to calculating any copayments or other insurance charges). Although the EPSDT program in Iowa requires a referral of all Medicaid-enrolled children to a dentist at 1 year of age, fewer than 4% of enrolled children in this age group received any dental services. The percent of enrolled children receiving a dental exam during FY 1994, by age, was as follows: younger than 1 year, 0.2%; age 1, 3%; age 2, 10%; age 3, 27%; age 4, 46%; age 5, 54%. Utilization rates of dental services by Medicaid-enrolled children in Iowa fall far short of federal regulations, which currently require that 80% of enrollees receive EPSDT screenings, referrals, and treatment by age 3.


Assuntos
Assistência Odontológica para Crianças/estatística & dados numéricos , Medicaid/estatística & dados numéricos , Fatores Etários , Criança , Pré-Escolar , Assistência Odontológica para Crianças/economia , Honorários Odontológicos/estatística & dados numéricos , Humanos , Lactente , Iowa , Medicaid/economia , Estados Unidos
20.
Pediatr Dent ; 20(3): 181-7, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9635314

RESUMO

PURPOSE: This cross-sectional study examined whether referrals from nondental health professionals impacted utilization of dental services by low-income populations. METHODS: A sample of 309 mothers enrolled in the Women, Infant, and Children (WIC) clinic in Jackson County, Missouri, completed a self-administered, 32-item questionnaire to assess the mother and child's oral health behavior and past use of dental services. Dental utilization, the primary dependent variable, was defined as whether or not the child had ever been to a dentist. RESULTS: Findings showed 27% of the children in the sample had been referred for dental care. Bivariate analysis indicated that a dental referral, age of the child, age of the mother, mother's perceived dental need for the child, household size, number of children in the household, and dental insurance for the child were associated with a child having a dental visit. Logistic regression, however, indicated that only age was significantly related to utilization. CONCLUSION: The results showed a strong effect of increasing age being related to dental utilization, while additional research is needed to clarify the importance of WIC referrals.


Assuntos
Assistência Odontológica para Crianças/estatística & dados numéricos , Programas de Rastreamento , Centros de Saúde Materno-Infantil , Doenças da Boca/prevenção & controle , Pobreza , Encaminhamento e Consulta , Doenças Dentárias/prevenção & controle , Adolescente , Adulto , Fatores Etários , Análise de Variância , Atitude Frente a Saúde , Pré-Escolar , Estudos Transversais , Características da Família , Feminino , Comportamentos Relacionados com a Saúde , Necessidades e Demandas de Serviços de Saúde , Humanos , Lactente , Seguro Odontológico , Modelos Logísticos , Idade Materna , Pessoa de Meia-Idade , Missouri , Saúde Bucal , Paridade , Inquéritos e Questionários
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