Modeling the effects of caffeine on the sleep/ wake cycle.

Caffeine is present in many products consumed daily, including coffee, soda, and chocolate, and is known to delay the onset of sleepiness and cause sleep disturbances. It is an adenosine antagonist, inhibiting some hormones that promote sleep, and therefore promoting wakefulness. This paper proposes a model to incorporate the effects of caffeine on the sleep/wake cycle. The “flip-flop” model was used to model the sleep cycle, where switching between a sleep state and a wake state was nearly instantaneous. Sleep patterns were modeled based on the circadian rhythm and homeostatic drive, as was done by Rempe et al. (2010). The model demonstrated how the homeostatic drive and circadian rhythm interact to cause sleep and wakefulness. The effects of caffeine were incorporated to have a masking effect on the homeostatic drive, promoting wakefulness. Preliminary results showed that caffeine intake late in the evening caused the switch from wake to sleep to occur later than if no caffeine was present in the system. Additionally, the switch from wake to sleep was increasingly delayed with increased caffeine intake at the same time. This model is not yet validated, though potential studies for validation are proposed. This model presents an interesting method for incorporating the effects of caffeine on the sleep/wake cycle.

Fatality risk in motorcycle collisions with roadside objects in the United States.

Motorcycle crashes with roadside objects often involve more than one impact event: typically involving a collision with the ground and another object. The objective of this study was to determine the fatality risk in these roadside object collisions when compared with crashes only involving a collision with the ground. The roadside objects analyzed included guardrails, concrete barriers, signs, utility poles, and trees. The Fatality Analysis Reporting System (FARS) database was used in conjunction with the General Estimates System (GES) to analyze fatality risk for motorcycle crashes from 2004 to 2008. The analysis was based upon over 3600 fatal motorcycle crashes with roadside objects. Collisions with roadside objects were found to have a higher fatality risk than collisions with either the ground or another motor vehicle. Based on the most harmful event reported in the crash, motorcycle collisions with guardrail were 7 times more likely to be fatal than collisions with the ground, and collisions with trees were almost 15 times more likely to be fatal than collisions with the ground. Additionally, the roadside object was reported as the most harmful event in the majority of the crashes in fatal two-event crashes involving a roadside object and a collision with the ground, with the exception of collisions with signage. From these analyses it was concluded that collisions with fixed objects are more harmful to motorcyclists than collisions with the ground.