Detalhe da pesquisa
1.
Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
Drug Metab Dispos
; 41(3): 541-5, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23230131
2.
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
Cancer Res
; 65(15): 6593-600, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061639
3.
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.
Eur J Pharm Sci
; 27(5): 524-32, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337112
4.
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Mol Cancer Ther
; 4(5): 855-63, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15897250
5.
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
J Med Chem
; 48(16): 5305-20, 2005 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16078848
6.
Identification and characterization of the canine multidrug resistance-associated protein.
Mol Cancer Ther
; 1(14): 1335-42, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12516967
7.
Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey.
Mol Cancer Ther
; 2(3): 307-16, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657726
8.
Considerations in the design and development of transport inhibitors as adjuncts to drug therapy.
Adv Drug Deliv Rev
; 55(1): 133-50, 2003 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12535578
9.
Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Biochem Pharmacol
; 67(6): 1111-21, 2004 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006547
10.
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin.
J Pharm Sci
; 93(7): 1743-54, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15176063
11.
Characterization and application of a vinblastine-selected CACO-2 cell line for evaluation of p-glycoprotein.
In Vitro Cell Dev Biol Anim
; 38(7): 401-10, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12534340
12.
Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.
Clin Cancer Res
; 19(5): 1159-68, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23325581
13.
Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.
Mol Cancer Ther
; 12(4): 481-90, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23371859
14.
Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis.
Mol Cancer Ther
; 11(3): 680-9, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22188817
15.
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
J Med Chem
; 52(22): 6958-61, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19860433
16.
Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).
Bioorg Med Chem Lett
; 15(24): 5526-30, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16202586
17.
A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.
Anal Biochem
; 310(1): 61-6, 2002 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12413474
18.
Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.
Int J Cancer
; 103(1): 121-5, 2003 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12455064
19.
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Mol Pharmacol
; 61(5): 964-73, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11961113
20.
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.
Mol Pharmacol
; 61(5): 974-81, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11961114