Detalhe da pesquisa
1.
Flexibility in Drug Product Development: A Perspective.
Mol Pharm
; 18(7): 2455-2469, 2021 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165309
2.
Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.
Mol Pharm
; 14(5): 1634-1645, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329443
3.
Preclinical dose number and its application in understanding drug absorption risk and formulation design for preclinical species.
Mol Pharm
; 12(4): 1031-9, 2015 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671350
4.
Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery.
J Med Chem
; 65(3): 1685-1694, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35060378
5.
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(21): 16213-16241, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714078
6.
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J Med Chem
; 64(7): 3911-3939, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33755451
7.
Reversible bridge-mediated excited-state symmetry breaking in stilbene-linked DNA dumbbells.
J Phys Chem B
; 112(12): 3838-43, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18318529
8.
Compatible injection and detection systems for studying the kinetics of excess electron transfer.
Org Lett
; 9(9): 1837-40, 2007 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17373807
9.
The influence of guanine on DNA hole transport efficiency.
Angew Chem Int Ed Engl
; 47(20): 3798-800, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18398887
10.
Detailed study of precipitation of a poorly water soluble test compound using methodologies as in activity and solubility screening - mixing and automation effects.
Comb Chem High Throughput Screen
; 16(8): 636-43, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713459
11.
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
Cancer Discov
; 3(7): 742-50, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23614898
12.
Dynamics and efficiency of DNA hole transport via alternating AT versus poly(A) sequences.
J Am Chem Soc
; 129(49): 15130-1, 2007 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020341
13.
Hole mobility in DNA a tracts.
Angew Chem Int Ed Engl
; 45(47): 7982-5, 2006 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17072927
14.
Dynamics and efficiency of electron injection and transport in DNA using pyrenecarboxamide as an electron donor and 5-bromouracil as an electron acceptor.
J Phys Chem B
; 114(45): 14265-72, 2010 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20121242
15.
Structure and photoinduced electron transfer in DNA hairpin conjugates possessing a tethered 5'-pyrenecarboxamide.
J Phys Chem B
; 113(50): 16276-84, 2009 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19842616
16.
Getting to guanine: mechanism and dynamics of charge separation and charge recombination in DNA revisited.
Photochem Photobiol Sci
; 7(5): 534-9, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18465008
17.
Photoinduced charge separation in pyrenedicarboxamide-linked DNA hairpins.
Photochem Photobiol Sci
; 7(12): 1501-8, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19037503
18.
Crossover from superexchange to hopping as the mechanism for photoinduced charge transfer in DNA hairpin conjugates.
J Am Chem Soc
; 128(3): 791-800, 2006 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16417368
19.
Dynamics and mechanism of bridge-dependent charge separation in pyrenylurea-nitrobenzene pi-stacked protophanes.
J Am Chem Soc
; 128(14): 4792-801, 2006 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16594716
20.
Solvent polarity effects and limited acid catalysis in rearrangements of model radicals for the methylmalonyl-CoA mutase- and isobutyryl-CoA mutase-catalyzed isomerization reactions.
J Am Chem Soc
; 126(17): 5368-9, 2004 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15113202