Detalhe da pesquisa
1.
Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.
Eur J Clin Pharmacol
; 76(10): 1393-1400, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32556539
2.
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.
Mol Pharm
; 8(4): 1332-41, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21707071
3.
Imeglimin Does Not Induce Clinically Relevant Pharmacokinetic Interactions When Combined with Either Metformin or Sitagliptin in Healthy Subjects.
Clin Pharmacokinet
; 59(10): 1261-1271, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32270440
4.
Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.
Eur J Drug Metab Pharmacokinet
; 45(6): 725-733, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860624
5.
Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.
Drug Metab Dispos
; 37(7): 1528-38, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19359404
6.
Effect of chronic exposure to morphine on the rat blood-brain barrier: focus on the P-glycoprotein.
J Neurochem
; 107(3): 647-57, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18761714
7.
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
J Neurochem
; 107(6): 1518-28, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19094056
8.
ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders.
Expert Opin Drug Metab Toxicol
; 6(10): 1161-74, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843279
9.
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.
Biochem Pharmacol
; 77(5): 897-909, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19041851