Detalhe da pesquisa
1.
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.
Bioorg Med Chem
; 25(16): 4512-4525, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28689977
2.
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
J Immunol
; 194(8): 3723-34, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762782
3.
Palliative interventional pulmonology procedures in the incarcerated population with cancer: a case series.
Lung
; 192(6): 915-20, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25015172
4.
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.
J Allergy Clin Immunol
; 132(4): 959-68, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683463
5.
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
J Med Chem
; 67(2): 1544-1562, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38175811
6.
Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging.
Sci Rep
; 12(1): 157, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34997110
7.
Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
JCI Insight
; 7(13)2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801586
8.
Cantharidin-Induced Skin Blister as an In Vivo Model of Inflammation.
Curr Protoc
; 1(2): e49, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33600079
9.
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.
J Med Chem
; 64(4): 1889-1903, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33592148
10.
Fluorescent nanoprobes as a biomarker for increased vascular permeability: implications in diagnosis and treatment of cancer and inflammation.
Bioconjug Chem
; 21(1): 93-101, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19958018
11.
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.
Bioorg Med Chem Lett
; 20(15): 4719-23, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20591669
12.
Erratum to: Palliative interventional pulmonology procedures in the incarcerated population with cancer: a case series.
Lung
; 193(2): 319, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666901
13.
Targeting interleukin-4 to the arthritic joint.
J Control Release
; 326: 172-180, 2020 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32653504
14.
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 63(10): 5102-5118, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083858
15.
Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.
ACS Med Chem Lett
; 10(10): 1467-1472, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620235
16.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
J Med Chem
; 62(23): 10816-10832, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729873
17.
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
J Med Chem
; 61(15): 6724-6735, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990434
18.
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
PLoS One
; 12(11): e0188391, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155882
19.
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.
JCI Insight
; 2(5): e91127, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289717
20.
Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Sci Rep
; 7(1): 13591, 2017 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29051536