1.
J Infect Dis
; 224(10): 1690-1693, 2021 11 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34514509
RESUMO
Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials.
Assuntos
COVID-19 , Imunidade Humoral , Anticorpos Antivirais , Vacina BNT162 , COVID-19/prevenção & controle , Humanos , Casas de Saúde , RNA , Vacinação
2.
Clin Infect Dis
; 73(11): 2145-2147, 2021 12 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33825869