RESUMO
In a 'blinded' trial (in Sri Lanka, 1996-98) of 47 male asymptomatic microfilaraemic subjects with Wuchereria bancrofti infection, the safety, tolerability and filaricidal efficacy of 3 single-dose combination regimens were compared: albendazole 400 mg with ivermectin 200 micrograms/kg, albendazole 400 mg with diethylcarbamazine citrate (DEC) 6 mg/kg or albendazole 600 mg with ivermectin 400 micrograms/kg. Treated subjects were followed-up for 24 months. This represents the first long-term study using combinations of albendazole with DEC or ivermectin in the above doses against bancroftian filariasis. All subjects had pre-treatment microfilaria (mf) counts over 100/mL. All 3 treatments significantly reduced mf counts, with the albendazole-DEC-treated group showing the lowest mf levels at 18 and 24 months post-treatment. Filarial antigen tests suggested that all 3 treatments had significant activity against adult W. bancrofti; albendazole-DEC combination had the greatest activity according to this test, with antigen levels decreasing to 30.5% of pre-treatment antigen levels, 24 months after therapy. All 3 treatments were clinically safe and well tolerated. These results suggest that a single dose of albendazole 400 mg together with DEC 6 mg/kg is a safe and effective combination for suppression of microfilaraemia of bancroftian filariasis that could be considered for use in filariasis control programmes based on mass treatment of endemic populations.
Assuntos
Albendazol/administração & dosagem , Antimaláricos/administração & dosagem , Dietilcarbamazina/administração & dosagem , Filariose Linfática/tratamento farmacológico , Ivermectina/administração & dosagem , Adolescente , Adulto , Análise de Variância , Combinação de Medicamentos , Feminino , Humanos , Assistência de Longa Duração , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
The current study was an investigation into intra-session changes in the pattern of Stroop colour-naming impairments with body shape-related words and food-related words. The subject pool comprised anorexic women and a control group of non-clinically disordered women. The results indicated that anorexic women show greater colour-naming decrements that non-disordered controls for both types of eating-related words. Stroop interference significantly decreased across the course of the experiment with the body-shape words for the anorexic subjects, thereby indicating habituation to the semantic content of those words. There was no comparable process of habituation observed with the food-related words.