Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia.

Quantitative magnetic resonance imaging (MRI) was used to investigate volumes of different brain structures in 19 patients with late-onset major depression (DSM-III-R), 27 patients with Alzheimer's disease (NINCDS-ADRDA criteria) and 13 age matched controls. 3-D MRI sequences were acquired using a Siemens 1.5 T scanner. Whole brain volume, CSF volume, volume of the frontal and temporal lobes and the volume of the amygdala-hippocampus complex were assessed using the software NMR Win. Compared to the controls, depressed patients showed a significantly lower whole brain volume and a significantly higher CSF volume, whereas volumes of the frontal and temporal lobes as well as the amygdala-hippocampus complex volumes were not significantly decreased. In addition, depressed patients exhibited a higher ventricle-brain ratio suggesting a higher degree of central atrophy compared to healthy individuals. In contrast, Alzheimer patients showed significantly lower volumes than depressed patients and controls with respect to all volumetric parameters. Although the findings indicate the presence of brain atrophy in patients with late-onset depression, the pattern of volumetric changes in these patients differs markedly from that observed in patients with primary degenerative dementia.

[The symptomology of akathisia]. / Zur Symptomatologie der Akathisie.

The phenomenon of akathisia is characterised by a subjective feeling of inner agitation accompanied by general motoric restlessness, which particularly affects the legs. It is mainly the inner agitation from which the patients suffer, but which they often cannot describe in any detail. The psychopathology of akathisia is presented in a case report, the emphasis being on a detailed description of inner agitation. Furthermore, motor, affective and cognitive symptoms of akathisia are pointed out. Finally, differential diagnosis of akathisia and standardised scales for assessment are discussed.

[Schizophrenia concepts in Soviet and Russian psychiatry]. / Schizophreniekonzepte in der sowjetischen und russischen Psychiatrie.

Concepts of schizophrenia of the Soviet Russian school are presented. They are historically based upon the broad concepts of schizophrenia by Kraepelin and Bleuler. The relationships to the German concept of "Einheitspsychose" (unitary psychosis) is emphasized. Along with the discussion of correspondence to and differences with Western diagnostic systems (DSM, ICD) it is pointed out that the old Soviet system of classification extends to psychotic and also non-psychotic forms which in ICD-10 are not attributed to schizophrenia, but to other categories. Differential-diagnostic criteria of sluggish schizophrenia and neurosis, such as positive psychopathological symptoms, thought disturbances and changes in personality, will be delineated. Furthermore, recent developments in Russian psychiatry and modifications in Russian schizophrenia concepts will be exemplified by the concept of "psychic diathesis."