Detalhe da pesquisa
1.
Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care.
Br J Cancer
; 130(6): 961-969, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272963
2.
Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients.
Br J Cancer
; 130(11): 1866-1874, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38532102
3.
Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations.
BMC Biotechnol
; 23(1): 36, 2023 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37684623
4.
Functional and targeted proteomics characterization of a human primary endothelial cell model of the blood-brain barrier (BBB) for drug permeability studies.
Toxicol Appl Pharmacol
; 465: 116456, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918128
5.
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations.
Pharm Res
; 40(11): 2687-2697, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37821769
6.
Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping.
J Pharmacokinet Pharmacodyn
; 49(6): 625-644, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36316606
7.
Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection.
Int J Mol Sci
; 23(21)2022 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361546
8.
TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model.
Int J Mol Sci
; 23(20)2022 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293329
9.
The role of brain barriers in the neurokinetics and pharmacodynamics of lithium.
Pharmacol Res
; 166: 105480, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549730
10.
Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation.
Mol Pharm
; 16(3): 1312-1326, 2019 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721081
11.
Sodium Transporters Are Involved in Lithium Influx in Brain Endothelial Cells.
Mol Pharm
; 15(7): 2528-2538, 2018 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29874916
12.
Double or Simple Emulsion Process to Encapsulate Hydrophilic Oxytocin Peptide in PLA-PEG Nanoparticles.
Pharm Res
; 35(4): 82, 2018 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29508092
13.
[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model.
Molecules
; 23(6)2018 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29875332
14.
Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels.
J Neurochem
; 142(4): 597-609, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581635
15.
The effect of morbid obesity on morphine glucuronidation.
Pharmacol Res
; 118: 64-70, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27609660
16.
Liquid chromatography high resolution mass spectrometry for the determination of baclofen and its metabolites in plasma: Application to therapeutic drug monitoring.
Biomed Chromatogr
; 31(8)2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28087970
17.
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Mol Pharmacol
; 89(5): 492-504, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26893303
18.
Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.
Mol Pharm
; 13(3): 766-73, 2016 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751618
19.
Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.
Mol Pharm
; 13(8): 2631-40, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27347605
20.
Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells.
J Neurochem
; 132(4): 373-83, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25327972