[Possible ways of correcting disorders of the amino acid content of the blood serum and gastric mucosa during treatment of peptic ulcer]. / Vozmozhnye puti korrektsii v protsesse lecheniia narushennogo aminokislotnogo sostava syvorotki krovi i slizistoi zheludka u bol'nykh iazvennoi bolezn'iu.

Investigations made by the authors permit the conclusion that in order to correct the disturbed amino acid content of the gastric mucosa and blood serum, mirroring the trends in the catabolic processes occurring in the body and disorder of liver amino acid-forming function, it is necessary to include the drugs eliminating the causes of the disorders (e. g. neurogenic dystrophy), stimulants of protein synthesis and amino acid preparations as structural material for proteins into the complex of treatment measures.

[Disorders of amino acid pool in the blood and gastric mucosa in patients with peptic ulcer]. / Narushenie aminokislotnogo fonda syvorotki krovi i slizistoi obolochki zheludka u bol'nykh iazvennoi bolezn'iu.

It has been demonstrated that peptic ulcer patients manifest hypo- and dysaminoacidemia and a dramatic increase in the amino acid pool of the gastric mucosa which are accounted for by neurogenic dystrophy leading to catabolic orientation of the processes not only in the mucous membrane of the gastroduodenal zone but also in other organs with a high level of protein synthesis, particularly in the liver. Based on the coefficients that determine amino acid transformation in the liver and analysis of the blood serum content of replaceable amino acids, peptic ulcer patients were discovered to have marked impairment of the amino acid-forming function of the liver.

[Degree of lipid peroxidation and vitamin E level during the treatment of peptic ulcer]. / Uroven' perekisnogo okisleniia lipidov i kontsentratsiia vitamina E pri lechenii bol'nykh iazvennoi bolezn'iu.

The study of 468 ulcer patients treated by laser irradiation plus choline blocking agents with adjuvant alpha-tocopherol antioxidants (alpha-tocopherol acetate, wild rose and sea-buckthorn oils) provided evidence in favour of the antioxidants addition. Combination of hyperbaric oxygenation (5-6 sessions) or riboxin with choline blocking agents made antioxidants unnecessary. Biochemical findings (vitamin E and malonic dialdehyde concentrations), electron microscopic, ++histo-enzyme and amino acids studies supported the clinical evidence.

[Nondrug methods in the combined treatment of peptic ulcer patients]. / Nemedikamentoznye metody v kompleksnom lechenii bol'nykh iazvennoi bolezn'iu.

Use of treatment complexes including non-drug methods (auricular acupuncture, pathogenetic dietotherapy, ILBR) or reduced doses of modern pharmacopreparations allowed to achieve rapid clinical and endoscopic remission in patients with ulcer disease. Simultaneously occurs normalization of the aggressive and defensive properties of the gastric juice, immunological, microcirculatory changes in the body and gastroduodenal mucosa. The vascular laser blood radiation reduced antacid dose and pathogenetic dietotherapy.

[The ultrastructural, histomorphological and histoenzymological changes in the gastric mucosa in different forms of chronic gastroduodenitis]. / Ul'trastrukturnye, gistomorfologicheskie i gistoénzimologicheskie izmeneniia slizistoi obolochki zheludka pri razlichnykh formakh khronicheskogo gastroduodenita.

Investigations designed to study gastric mucosa (GM) in patients with chronic primary gastroduodenitis with the aid of electron microscopy showed the abnormal changes in the cellular, subcellular membranes and capillaries to be of the same type as they are in peptic ulcer (PU) though poorly manifest. Changes in GM under chronic atrophic gastroduodenitis (ChGD) suggested involutive changes while in chronic secondary gastroduodenitis (ChSGD) it was generally not different from the mucosa ultrastructure in healthy subjects except for changes in surface epithelium. Based on the histoenzymologic studies it has been ascertained that in ChPGD there occurs a rise in lysosomal enzymes similar to that encountered in PU, reflecting the intensity of catabolic processes, decrease in the activity of enzymes of the capillary wall and mitochondria respiratory chain against the background of compensatory enhancement of the activity of the glycolytic enzyme lactate dehydrogenase. In ChAGD the activity of all the enzymes was low, while in ChSGD it did not differ significantly from that in healthy subjects.

[The use of tardyferon in the combined treatment of patients with chronic atrophic gastritis and peptic ulcer complicated by hemorrhage]. / Primenenie tardiferona v kompleksnom lechenii bol'nykh khronicheskim atroficheskim gastritom i iazvennoi bolezn'iu, oslozhnennoi krovotecheniem.

Tardipherone is capable of maximum absorption in the initial portion of small intestine, iron being in its retarding form, which fact ensures a prolonged action of the drug, mucoprotease being a part of tardipherone composition acting to guard gastric and duodenal mucosae against irritating effect of iron. Tardipherone was found to be efficacious in treating patients with ulcer disease complicated by bleeding. Under its effect the hemogram indices get normalized as does the ratio of aggressive to protective factors of gastric juice, which factors play a major part in the emergent relapse of the illness. The use of tardipherone was found to be justified in the treatment of patients with chronic atrophic gastritis, being associated with gratifying shifts in the clinical picture of the condition and improvement in the hemogram characteristics.

[The use of the hypoglycemic preparation gliquidone in patients with digestive organ diseases combined with diabetes mellitus]. / Primenenie sakharosnizhaiushchego preparata glikvidona u bol'nykh s zabolevaniiami organov pishchevareniia v sochetanii s sakharnym diabetom.

A peroral sugar-reducing preparation gliquidone (glurenorm) was tried in treatment of 66 patients with digestive diseases (peptic ulcer, chronic pancreatitis, cirrhosis of the liver), presenting with diabetes mellitus. The results of the studies made showed glurenorm to be a highly effective preparation in term of both its sugar-reducing effect and its capability to improve energy processes in gastric and duodenal mucosa, pancreacytes, hepatocytes, besides which, it appear to dispel metabolic disturbances and stimulate reparative processes in body organs, improves protein-synthetic processes in the liver, pancreas, mucosa of the gastroduodenal region.

[The histoenzymological and ultrastructural changes in the gastric mucosa in peptic ulcer after treatment with pirenzepine and histamine H2-receptor blockaders]. / Gistoénzimologicheskie i ul'trastruktivnye izmeneniia slizistoi obolochki zheludka pri iazvennoi bolezni posle lecheniia pirentsepinom i H2-blokatorami gistaminoretseptorov.

A study made in 72 patients showed a positive influence in ulcer disease of gastrocepine and H2-blockers of receptors to histamine on histoenzymological and ultrastructural changes in the mucous membrane of the stomach and duodenum. Gastrocepine was found to be superior to H2-blockers of receptors to histamine due to its apparent cytoprotective effect and ability to improve microcirculation.

[The use of 3rd-generation antacid preparations for the treatment of patients with nonulcerous dyspepsia and peptic ulcer complicated by reflux esophagitis]. / Primenenie antatsidnykh preparatov III pokoleniia dlia lecheniia bol'nykh neiazvennoi dispepsiei i iazvennoi bolezn'iu, oslozhnennoi refliuks-ézofagitom.

In the present investigation on the treatment of patients with nonulcerous dyspepsia and peptic ulcer, hiatus hernia complicated with reflux esophagitis, a mechanism has been studied of the action of topalkan, a 3rd generation aluminium-magnesium antacid, that involves not only its antacid properties but in an even greater degree the availability of alginic acid in its formula which has antipeptic and protective effect with respect of the mucous membrane of the stomach and esophagus, and provides, together with the magnesium salts, a floating layer of the preparation in the stomach. In grave course of nonulcerous dyspepsia (preulcerous condition) and peptic ulcer complicated by reflux disease of the esophagus topalkan was used in combination with present-day antisecretory preparations pyrenzepine or H2-blockaders of histamine receptors capable of enhancing the antisecretory effect of topalkan as well as endowed with cytoprotective properties with respect of the mucous membrane of the stomach and duodenum promoting healing of erosions and healing and scarring of ulcerous defects.

[The omeprazole treatment of patients with diseases of the upper digestive tract]. / Lechenie omeprazolom bol'nykh s zabolevaniiami verkhnikh otdelov pishchevaritel'nogo kanala.

Effectiveness of the use of Omeprazolum (Oside) was studied in 24 patients with ulcer disease, 16 patients with chronic primary gastroduodenitis and 18 patients with acid reflux-esophagitis. The preparation Oside is a highly effective agent for the treatment of the aforementioned conditions and possesses a powerful antisecretory and antioxidant activity. Against the background of the use of the preparation the count of Helicobacter pylori gets decreased in the antral part of the stomach. The use of the preparation is not accompanied by side-effects and it does not have reverse acidic effect, in which respect has been shown to be superior to H2-histamine blockers.

[The use of the immunomodulating action of intravascular laser irradiation of the blood in treating peptic ulcer patients]. / Ispol'zovanie immunomoduliruiushchego deistviia vnutrisosudistogo lazernogo oblucheniia krovi pri lechenii bol'nykh iazvennoi bolezn'iu.

Intravascular laser radiation of the blood was employed in 68 patients with ulcer disease in the complex treatment with antacid; cholinolytic, antioxidant agents. The employment of helium-neon laser as an immunomodulator resulted in an improvement of indices of cellular and humoral immunity, normalization of lipid peroxidation, increased resistance of the gastric and duodenal mucosa, reduction of the time of scarring of the ulcer defect against the background of rapid clinical remission, increase of the interrecurrence period.

[The prevention of stress-related postoperative and drug-induced erosive-ulcerative lesions of the upper digestive tract]. / Preduprezhdenie stressovykh posleoperatsionnykh i medikamentoznykh érozivno-iazvennykh porazhenii verkhnikh otdelov pishchevaritel'nogo kanala.

Based on the studies made in 84 patients with calculous cholecystitis and 12 patients with calcifying pancreatitis, an efficiency was shown of infusional administration of pyrencepine or ranitidine to prevent stress postoperative erosive-and-ulcerous lesions of gastroduodenal zone. Gastrocepine is shown to be superior to ranitidine and can be withdrawn without a maintenance dose, as well as becouse its cytoprotective effects with respect of the gastric and duodenal mucosa.

[The use of Smecta for the treatment of the basic digestive tract diseases]. / Primenenie smekty dlia lecheniia osnovnykh zabolevanii pishchevaritel'nogo kanala.

The indices for the gastric contents aggression and protection ratio returned to normal in patients with peptic ulcer and preulcerous condition during the treatment with smekta due to a decrease in proteolytic activity and increase in the synthesis of the mucus protective proteins. Monitoring of intragastric pH in the body of the stomach throughout 24 hours in patients with peptic ulcer of duodenal location revealed significant acid-neutralizing effect of smekta. Patients with nonspecific ulcerous colitis enjoyed freedom of side effects as a result of the use of salofalk and derived full therapeutic benefit from this treatment. Under the effect of smekta there occurred suppression of the growth of pathogenic proteolytic flora, improvement of qualitative properties of coli flora and growth of sugar-lytic flora in patients with intestinal dysbiosis. According to the data available, smekta strengthens the mucous barrier by improving the conformation of the mucus structural elements.