Detalhe da pesquisa
1.
Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 30(7): 126986, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32046903
2.
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Bioorg Med Chem
; 28(1): 115208, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740203
3.
Pooled Resistance Analysis in Patients with Hepatitis C Virus Genotype 1 to 6 Infection Treated with Glecaprevir-Pibrentasvir in Phase 2 and 3 Clinical Trials.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30061289
4.
Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180522
5.
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29084747
6.
Resistance characterization of hepatitis C virus genotype 2 from Japanese patients treated with ombitasvir and paritaprevir/ritonavir.
J Med Virol
; 90(1): 109-119, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28842997
7.
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193664
8.
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(22): 5462-5467, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780635
9.
Hepatitis C virus genotype 4 resistance and subtype demographic characterization of patients treated with ombitasvir plus paritaprevir/ritonavir.
Antimicrob Agents Chemother
; 59(11): 6807-15, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26282418
10.
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450.
Antimicrob Agents Chemother
; 59(2): 988-97, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451053
11.
Hepatitis C virus genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with glecaprevir and pibrentasvir.
PLoS One
; 13(10): e0205186, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30286205
12.
Resistance Analysis of a 3-Day Monotherapy Study with Glecaprevir or Pibrentasvir in Patients with Chronic Hepatitis C Virus Genotype 1 Infection.
Viruses
; 10(9)2018 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30154359
13.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 61(9): 4052-4066, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653491
14.
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro.
Antiviral Res
; 73(1): 78-83, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16945431
15.
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.
Antiviral Res
; 76(1): 93-7, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17561278
16.
A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.
J Virol Methods
; 145(2): 137-45, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17604129
17.
Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir.
Antiviral Res
; 59(3): 173-80, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12927307
18.
P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses.
J Med Chem
; 54(20): 7094-104, 2011 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21899332
19.
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
J Med Chem
; 52(8): 2571-86, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19323562
20.
Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.
Antimicrob Agents Chemother
; 52(4): 1337-44, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18212102