Detalhe da pesquisa
1.
Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity.
Bioorg Med Chem Lett
; 92: 129409, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37453616
2.
Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies.
Blood
; 129(1): 88-99, 2017 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27784673
3.
Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability.
Prostaglandins Other Lipid Mediat
; 136: 90-95, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29567338
4.
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 23(2): 417-21, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23237835
5.
EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex.
Biometals
; 26(6): 1041-50, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24158698
6.
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Nat Chem Biol
; 6(8): 602-9, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20581821
7.
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 22(1): 601-5, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079754
8.
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.
J Comput Aided Mol Des
; 25(9): 873-83, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904909
9.
Locations of the beta1 transmembrane helices in the BK potassium channel.
Proc Natl Acad Sci U S A
; 105(31): 10727-32, 2008 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669652
10.
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.
Proc Natl Acad Sci U S A
; 105(6): 2198-202, 2008 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18268335
11.
Location of the beta 4 transmembrane helices in the BK potassium channel.
J Neurosci
; 29(26): 8321-8, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19571123
12.
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.
J Neurosci
; 29(25): 8075-86, 2009 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553447
13.
Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease.
Biochem Pharmacol
; 176: 113818, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978378
14.
N-quinoline-benzenesulfonamide derivatives exert potent anti-lymphoma effect by targeting NF-κB.
iScience
; 23(12): 101884, 2020 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33354662
15.
Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.
Neuropsychopharmacology
; 45(9): 1545-1556, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32417852
16.
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 19(8): 2354-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19303288
17.
Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.
Bioorg Med Chem Lett
; 19(4): 1191-4, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19136257
18.
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Bioorg Med Chem Lett
; 19(6): 1715-7, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19243939
19.
Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.
Mol Neurodegener
; 14(1): 26, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31248451
20.
Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade.
Mol Neurodegener
; 19(1): 39, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38685083