Detalhe da pesquisa
1.
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Proc Natl Acad Sci U S A
; 120(4): e2212338120, 2023 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649421
2.
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels.
Mol Pharmacol
; 105(3): 202-212, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302135
3.
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats.
Am J Physiol Renal Physiol
; 325(2): F177-F187, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37318990
4.
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Bioorg Med Chem Lett
; 87: 129256, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36966977
5.
The Molecular Physiology and Toxicology of Inward Rectifier Potassium Channels in Insects.
Annu Rev Entomol
; 67: 125-142, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606365
6.
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels.
Mol Pharmacol
; 101(5): 357-370, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35246480
7.
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.
Am J Physiol Cell Physiol
; 320(6): C1125-C1140, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33826405
8.
Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism.
Am J Physiol Cell Physiol
; 320(6): C1088-C1098, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33826406
9.
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology.
Am J Physiol Cell Physiol
; 320(3): C293-C303, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356947
11.
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Nature
; 520(7545): 94-8, 2015 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25600267
12.
CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
Am J Physiol Cell Physiol
; 317(4): C857-C866, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31390227
13.
G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1.
J Biol Chem
; 293(46): 17739-17753, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257863
14.
Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.
J Pharmacol Exp Ther
; 370(3): 350-359, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31201216
15.
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.
Bioorg Med Chem Lett
; 29(13): 1601-1604, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072652
16.
Special collection on inward rectifying K+ channels.
Am J Physiol Cell Physiol
; 324(3): C603-C605, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36689674
17.
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.
Mol Pharmacol
; 94(2): 926-937, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29895592
18.
Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.
Mol Pharmacol
; 92(3): 338-346, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28619748
19.
Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.
J Biol Chem
; 291(42): 21971-21983, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27573238
20.
ROMK inhibitor actions in the nephron probed with diuretics.
Am J Physiol Renal Physiol
; 310(8): F732-F737, 2016 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26661652