Detalhe da pesquisa
1.
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown.
J Autoimmun
; 142: 103152, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071801
2.
Synthesis, antitumor activity and DNA binding features of benzothiazolyl and benzimidazolyl substituted isoindolines.
Bioorg Med Chem
; 26(8): 1950-1960, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519603
3.
Targeting Transcription Factors for Cancer Treatment.
Molecules
; 23(6)2018 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29921764
4.
Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair.
Bioorg Med Chem Lett
; 25(21): 4927-4932, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26051649
5.
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.
Nucleic Acids Res
; 41(1): 125-38, 2013 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23093599
6.
Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts.
Int J Mol Sci
; 16(11): 26555-81, 2015 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26556350
7.
The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine.
Biochemistry
; 53(7): 1218-27, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495039
8.
Structure-dependent binding of arylimidamides to the DNA minor groove.
Chembiochem
; 15(1): 68-79, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24323836
9.
Protein recognition of the S23906-1-DNA adduct by nuclear proteins: direct involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Biochem J
; 452(1): 147-59, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23409959
10.
Induction of AML cell differentiation using HOXA9/DNA binding inhibitors as a potential therapeutic option for HOXA9-dependent AML.
Hemasphere
; 8(5): e77, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38716146
11.
Water-mediated binding of agents that target the DNA minor groove.
J Am Chem Soc
; 133(26): 10171-83, 2011 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21627167
12.
In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii.
Toxicol Appl Pharmacol
; 254(1): 8-17, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21504755
13.
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.
Nucleic Acids Res
; 36(10): 3341-53, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18440973
14.
Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities.
Mol Pharmacol
; 76(6): 1172-85, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19752199
15.
Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Bioorg Med Chem
; 17(5): 1918-27, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217791
16.
Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia.
Cancers (Basel)
; 11(6)2019 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31213012
17.
Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.
J Med Chem
; 62(3): 1306-1329, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30645099
18.
Novel amidino substituted benzimidazole and benzothiazole benzo[b]thieno-2-carboxamides exert strong antiproliferative and DNA binding properties.
Eur J Med Chem
; 136: 468-479, 2017 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28525845
19.
Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.
J Med Chem
; 57(24): 10329-42, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25360689
20.
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties.
Eur J Med Chem
; 71: 267-81, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24334150