Detalhe da pesquisa
1.
Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.
Bioorg Med Chem Lett
; 30(4): 126930, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31926786
2.
Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.
Drug Metab Dispos
; 42(1): 9-22, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24130370
3.
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: core region.
Bioorg Med Chem Lett
; 24(3): 989-94, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24411125
4.
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350).
Bioorg Med Chem Lett
; 24(3): 995-9, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412072
5.
HCV versus HIV drug discovery: Déjà vu all over again?
Bioorg Med Chem Lett
; 23(8): 2281-7, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23489621
6.
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
Bioorg Med Chem Lett
; 23(5): 1493-7, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375792
7.
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Bioorg Med Chem
; 18(10): 3606-17, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20409721
8.
Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Bioorg Med Chem
; 17(4): 1739-46, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19179082
9.
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
Clin Cancer Res
; 14(9): 2824-32, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18451250
10.
Synthesis and antibacterial activity of novel C12 vinyl ketolides.
J Med Chem
; 49(5): 1730-43, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509588
11.
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
J Med Chem
; 59(19): 9005-9017, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690427
12.
Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
J Med Chem
; 58(4): 1630-43, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25574686
13.
Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 2033-46, 2014 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24320933
14.
Rediscovering the role of natural products in drug discovery.
Curr Opin Drug Discov Devel
; 11(4): 436-7, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18600560
15.
Identifying quality leads - an important factor in reducing attrition of clinical candidates.
Curr Opin Drug Discov Devel
; 10(4): 381-2, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17659478
16.
Backup programs in drug discovery.
Curr Opin Drug Discov Devel
; 9(4): 412-3, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889224
17.
Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.
J Med Chem
; 59(16): 7696, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27529494
18.
The role of medicinal chemists in drug discovery.
Curr Opin Drug Discov Devel
; 8(4): 419-20, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16022177
19.
Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer.
ACS Med Chem Lett
; 1(5): 209-13, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900196
20.
Total Synthesis of (±)-Ginkgolide B.
J Am Chem Soc
; 110(2): 649-651, 1988 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527923