Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.
Bioorg Chem
; 130: 106238, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36403335
2.
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.
Bioorg Med Chem Lett
; 66: 128728, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35413417
3.
Heterogeneity in Economic and Carbon Benefits of Electric Technology Vehicles in the US.
Environ Sci Technol
; 54(2): 1136-1146, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31722175
4.
Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors.
Bioorg Chem
; 99: 103851, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32334196
5.
Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.
Bioorg Med Chem Lett
; 29(11): 1313-1319, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30975623
6.
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor.
Xenobiotica
; 49(10): 1164-1172, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30488748
7.
Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia.
Xenobiotica
; 48(1): 37-44, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28042744
8.
Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats.
Biomed Chromatogr
; 31(11)2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28370279
9.
Nonclinical Pharmacokinetic Evaluation of Desidustat: a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.
Eur J Drug Metab Pharmacokinet
; 47(5): 725-740, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35881329
10.
ZYKR1, a novel, potent, and peripherally selective kappa opioid receptor agonist reduces visceral pain and pruritus in animal models.
Eur J Pharmacol
; 924: 174961, 2022 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35443192
11.
Identification of novel and selective Kv2 channel inhibitors.
Mol Pharmacol
; 80(6): 959-64, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21948463
12.
ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.
Pharmacol Res Perspect
; 8(4): e00565, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32790160
13.
Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.
J Med Chem
; 61(24): 10976-10995, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30010338
14.
Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases.
J Med Chem
; 61(16): 6964-6982, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29712435
15.
Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1.
Cancer Chemother Pharmacol
; 82(4): 635-647, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046848
16.
ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase-4, for the treatment of Type 2 diabetes mellitus.
Br J Pharmacol
; 174(14): 2346-2357, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28452143
17.
A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization.
Bioanalysis
; 9(9): 719-732, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28488896
18.
Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model.
Drug Res (Stuttg)
; 67(4): 223-227, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28158894
19.
Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist.
ACS Med Chem Lett
; 7(12): 1134-1138, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994752
20.
Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist.
ACS Med Chem Lett
; 7(1): 51-5, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819665