Detalhe da pesquisa
1.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J Biol Chem
; 296: 100568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753169
2.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
3.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695224
4.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
5.
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Biochem Biophys Res Commun
; 487(2): 403-408, 2017 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416386
6.
Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.
Chemistry
; 21(20): 7394-8, 2015 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809883
7.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
8.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Cell Chem Biol
; 28(12): 1693-1702.e6, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192523
9.
Validating Signal Transducer and Activator of Transcription (STAT) Protein-Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays.
ACS Chem Biol
; 15(7): 1842-1851, 2020 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32412740
10.
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
J Pharm Biomed Anal
; 160: 80-88, 2018 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30086509
11.
The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition.
Cell Chem Biol
; 24(12): 1429-1431, 2017 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29272698
12.
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Medchemcomm
; 8(7): 1553-1560, 2017 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108867
13.
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Oncotarget
; 8(14): 23713-23726, 2017 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28423595
14.
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Science
; 355(6330): 1206-1211, 2017 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28302858
15.
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
J Med Chem
; 60(10): 4279-4292, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28508636
16.
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Nat Commun
; 6: 7871, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26238318
17.
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.
J Med Chem
; 56(15): 6190-9, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23819803
18.
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
J Med Chem
; 55(14): 6391-402, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22738293
19.
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.
J Med Chem
; 55(1): 68-83, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22098589
20.
Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
J Med Chem
; 60(17): 7614, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28862438