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1.
J Endocrinol Invest ; 44(4): 765-771, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32772324

RESUMO

PURPOSE: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis. METHODS: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. RESULTS: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019). CONCLUSIONS: High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.


Assuntos
COVID-19/epidemiologia , COVID-19/mortalidade , Insuficiência Respiratória/epidemiologia , Deficiência de Vitamina D/epidemiologia , Doença Aguda , Idoso , COVID-19/imunologia , Comorbidade , Síndrome da Liberação de Citocina , Feminino , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Fatores de Risco , SARS-CoV-2 , Índice de Gravidade de Doença , Vitamina D/sangue , Deficiência de Vitamina D/imunologia
2.
Eur J Clin Pharmacol ; 72(8): 1025-9, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27251359

RESUMO

PURPOSE: During interferon-ß (IFN-ß) therapy, up to 45 % of patients may develop neutralizing antibodies (NAbs), associated with a decreased efficacy of the drug. We investigated in a real-life setting the impact of NAbs on magnetic resonance imaging (MRI) outcomes in a population of 567 IFN-ß-treated relapsing-remitting (RR) multiple sclerosis (MS) patients up to 7 years. We also evaluated NAbs' role as a biomarker of the persistence of MRI disease activity. METHODS: Patients' sera were tested for NAbs' presence by cytopathic effect (CPE) assay every 6-12 months. MRI scans were performed every 12 months. Generalized hierarchical linear models accounting for within-patient correlation were used to analyze T1 gadolinium-enhancing and new T2 lesions. Moreover, further tests were carried out to assess the overall outcome difference from year 1 to year 7 according to NAb status and the possible interaction between NAb status and time of follow-up. RESULTS: Seventy-five patients (13.2 %) became NAb positive (NAb+) during the follow-up. Considering T1 gadolinium-enhancing (GD+) lesions, we observed a significantly higher incidence in NAb+ patients (52 %, p = 0.0091). Also for new T2 lesions, we found a higher incidence in NAb+ patients (50 %, p = 0.0075). The negative impact of NAbs on the MRI outcomes considered did not change during the follow-up. CONCLUSIONS: Our 7-year results show the negative effect of NAbs on MRI measures of disease activity and confirm their role as a surrogate marker of IFN-ß treatment efficacy.


Assuntos
Anticorpos Neutralizantes/sangue , Interferon beta/imunologia , Interferon beta/uso terapêutico , Esclerose Múltipla Recidivante-Remitente/tratamento farmacológico , Esclerose Múltipla Recidivante-Remitente/imunologia , Adolescente , Adulto , Biomarcadores/sangue , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Esclerose Múltipla Recidivante-Remitente/sangue , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto Jovem
3.
G Ital Med Lav Ergon ; 33(3 Suppl): 408-12, 2011.
Artigo em Italiano | MEDLINE | ID: mdl-23393888

RESUMO

The paper presents the results obtained thanks to an innovative experimental device for the assessment of artificial optical radiation (AOR) exposure in workplace. This . device was developed by 'Politecnico di Bari-DIASS'. The wearable personal dosimeter has three sensors: one is used for measuring head position/movement, therefore there is a color light sensor to determine the AOR and finally there is a video camera to localize sources. Our system is connected to a netbook via USB cable that allows one to obtain the real and extimated value of worker's exposure, also with "augmented reality". The aim of this paper is realizing work place safety zoning for the classifacation of not only specific dangerous areas through the analysis of overlapping information from the device.


Assuntos
Luz/efeitos adversos , Exposição Ocupacional/efeitos adversos , Proteção Radiológica/instrumentação , Desenho de Equipamento , Humanos , Radiometria
4.
J Neuroimmunol ; 303: 75-80, 2017 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-28043652

RESUMO

We investigated, lymphocyte count (LC) and lymphocyte subpopulations (LS) in a real life setting of Fingolimod (FTY) treated Relapsing MS (RMS) patients. Peripheral blood counts with LS, relapses and MRI scans were recorded in a cohort of 119 FTY patients, during one year of treatment. Simple and multivariate logistic regression models, were performed. ROC analysis identified cut-off values of LS predicting a higher risk of relapses and of Gd+ lesions. We demonstrated a FTY-induced re-modulation of the immune system, suggesting that LS in RMS FTY treated patients can predict the clinical response to the drug.


Assuntos
Cloridrato de Fingolimode/uso terapêutico , Imunossupressores/uso terapêutico , Subpopulações de Linfócitos/imunologia , Esclerose Múltipla Recidivante-Remitente/tratamento farmacológico , Esclerose Múltipla Recidivante-Remitente/imunologia , Adulto , Biomarcadores/sangue , Estudos de Coortes , Feminino , Cloridrato de Fingolimode/farmacologia , Seguimentos , Humanos , Imunossupressores/farmacologia , Subpopulações de Linfócitos/efeitos dos fármacos , Subpopulações de Linfócitos/metabolismo , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/sangue , Resultado do Tratamento
5.
Clin Ter ; 149(6): 413-7, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-10100402

RESUMO

OBJECTIVE: Several epidemiological and clinical reports have investigated the relationship between Helicobacter pylori (H. pylori) infection and ischemic heart disease (IHD). All studies utilized for the diagnosis of H. pylori infection the antibody titre that is unable to distinguish an actual from a previous H. pylori infection. PATIENTS AND METHODS: We report a retrospective analysis on 149 subjects, who underwent an esophago-gastro-duodenoscopy, in whom the search for H. pylori was histologically performed. RESULTS: The prevalence of IHD is not significantly different from that observed in H. pylori free patients (26% vs 21%, p = 0.527). CONCLUSIONS: The mechanism underlying the possible role of H. pylori needs further investigation and prospective studies to further analyze the relationship between "active" H. pylori infection and ischemic heart disease were necessary.


Assuntos
Doença das Coronárias/etiologia , Infecções por Helicobacter/diagnóstico , Helicobacter pylori , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Doença das Coronárias/epidemiologia , Feminino , Infecções por Helicobacter/complicações , Infecções por Helicobacter/patologia , Helicobacter pylori/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco , Estômago/microbiologia , Estômago/patologia
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