Detalhe da pesquisa
1.
Platform trials to overcome major shortcomings of traditional clinical trials in non-alcoholic steatohepatitis? Pros and cons.
J Hepatol
; 78(2): 442-447, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216134
2.
Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition.
Arterioscler Thromb Vasc Biol
; 38(9): 2207-2216, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30354257
3.
The Subclinical Cardiomyopathy of Friedreich's Ataxia in a Pediatric Population.
J Card Fail
; 24(10): 672-679, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986271
4.
Pharmacokinetics and pharmacodynamics of canagliflozin in pediatric patients with type 2 diabetes.
Pediatr Diabetes
; 19(4): 649-655, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271103
5.
Impaired mitochondrial function in psychiatric disorders.
Nat Rev Neurosci
; 13(5): 293-307, 2012 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22510887
6.
Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants.
Int J Clin Pharmacol Ther
; 53(2): 115-28, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25407255
7.
Rating disease progression of Friedreich's ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database.
Brain
; 136(Pt 1): 259-68, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365101
8.
Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
PLoS Genet
; 6(12): e1001240, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21170301
9.
Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.
PLoS Genet
; 6(1): e1000812, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20090835
10.
Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints.
PLoS One
; 18(3): e0281674, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893087
11.
Review article: The need for more efficient and patient-oriented drug development pathways in NASH-setting the scene for platform trials.
Aliment Pharmacol Ther
; 57(9): 948-961, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918740
12.
Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: A randomized dose-ranging study.
Clin Obes
; 11(2): e12433, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33475251
13.
Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy.
J Clin Invest
; 117(3): 659-71, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17318264
14.
Clinical features of spinal and bulbar muscular atrophy.
Brain
; 132(Pt 12): 3242-51, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19846582
15.
Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia.
Arch Phys Med Rehabil
; 91(7): 1044-50, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20599042
16.
Standard and modified statistical MUNE evaluations in spinal-bulbar muscular atrophy.
Muscle Nerve
; 40(5): 809-14, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19670325
17.
Clinical experience with high-dose idebenone in Friedreich ataxia.
J Neurol
; 256 Suppl 1: 42-5, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19283350
18.
Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics.
Neurobiol Dis
; 30(3): 365-374, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417352
19.
Predictors of progression in patients with Friedreich ataxia.
Mov Disord
; 23(14): 2026-32, 2008 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18759347
20.
Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial.
Lancet Neurol
; 6(10): 878-86, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17826341