Detalhe da pesquisa
1.
High-Dose Isoniazid Lacks EARLY Bactericidal Activity Against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized, Phase 2 Clinical Trial.
Am J Respir Crit Care Med
; 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38564365
2.
High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance.
PLoS Comput Biol
; 19(4): e1011000, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37053266
3.
Phase I Single Ascending Dose and Food Effect Study in Healthy Adults and Phase I/IIa Multiple Ascending Dose Study in Patients with Pulmonary Tuberculosis to Assess Pharmacokinetics, Bactericidal Activity, Tolerability, and Safety of OPC-167832.
Antimicrob Agents Chemother
; 67(6): e0147722, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37219453
4.
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
Antimicrob Agents Chemother
; 67(10): e0068323, 2023 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37768317
5.
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.
N Engl J Med
; 382(10): 893-902, 2020 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130813
6.
Relative bioavailability of delamanid 50 mg tablets dispersed in water in healthy adult volunteers.
Br J Clin Pharmacol
; 2023 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36692865
7.
Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.
Am J Respir Crit Care Med
; 205(10): 1228-1235, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258443
8.
Pharmacokinetics of bedaquiline in cerebrospinal fluid (CSF) in patients with pulmonary tuberculosis (TB).
J Antimicrob Chemother
; 77(6): 1720-1724, 2022 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35257182
9.
Sputum lipoarabinomannan (LAM) as a biomarker to determine sputum mycobacterial load: exploratory and model-based analyses of integrated data from four cohorts.
BMC Infect Dis
; 22(1): 327, 2022 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35366820
10.
Mycobacteriophages to Treat Tuberculosis: Dream or Delusion?
Respiration
; 101(1): 1-15, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34814151
11.
A Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical Trial.
Am J Respir Crit Care Med
; 204(11): 1327-1335, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403326
12.
Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.
Clin Infect Dis
; 73(2): e362-e370, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32590841
13.
Effect of Clofazimine Concentration on QT Prolongation in Patients Treated for Tuberculosis.
Antimicrob Agents Chemother
; 65(7): e0268720, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33875426
14.
Increased bactericidal activity but dose-limiting intolerability at 50â mg·kg-1 rifampicin.
Eur Respir J
; 58(1)2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33542056
15.
Comparing rates of mycobacterial clearance in sputum smear-negative and smear-positive adults living with HIV.
BMC Infect Dis
; 21(1): 466, 2021 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34022850
16.
Anton Ghon and His Colleagues and Their Studies of the Primary Focus and Complex of Tuberculosis Infection and Their Relevance for the Twenty-First Century.
Respiration
; 100(7): 557-567, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33321506
17.
The Utility of Pleural Fluid Lactate Dehydrogenase to Adenosine Deaminase Ratio in Pleural Tuberculosis.
Respiration
; 100(1): 59-63, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333531
18.
Early Bactericidal Activity of Different Isoniazid Doses for Drug-Resistant Tuberculosis (INHindsight): A Randomized, Open-Label Clinical Trial.
Am J Respir Crit Care Med
; 201(11): 1416-1424, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945300
19.
Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32122887
20.
Fourteen-Day Bactericidal Activity, Safety, and Pharmacokinetics of Linezolid in Adults with Drug-Sensitive Pulmonary Tuberculosis.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31988102