Detalhe da pesquisa
1.
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.
J Med Virol
; 96(4): e29594, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38576317
2.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35949003
3.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules
; 27(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36500508
4.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules
; 27(18)2022 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36144727
5.
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators.
Molecules
; 27(21)2022 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364467
6.
Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.
Retrovirology
; 18(1): 31, 2021 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34627310
7.
Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.
Bioorg Med Chem
; 48: 116414, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34562701
8.
Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate.
Biochem J
; 477(21): 4263-4280, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33057580
9.
Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors.
Biochemistry
; 59(6): 818-828, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31942789
10.
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Immunity
; 35(4): 514-25, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962493
11.
Recent Advances in HIV-1 Gag Inhibitor Design and Development.
Molecules
; 25(7)2020 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32272714
12.
Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity.
J Biol Chem
; 293(9): 3056-3072, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330299
13.
Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.
Molecules
; 24(8)2019 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013646
14.
Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.
Org Biomol Chem
; 15(37): 7770-7782, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28770939
15.
Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.
J Biol Chem
; 290(20): 12779-92, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25829498
16.
Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein.
Nucleic Acids Res
; 42(9): 6025-37, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24688060
17.
Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly.
Structure
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38749445
18.
The discovery and design of novel HIV-1 capsid modulators and future perspectives.
Expert Opin Drug Discov
; 18(1): 5-12, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36480372
19.
Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.
RSC Med Chem
; 14(7): 1272-1295, 2023 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37484571
20.
Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth.
bioRxiv
; 2023 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38187734