Detalhe da pesquisa
1.
Peripherally Restricted, Highly Potent, Selective, Aqueous-Soluble EP2 Antagonist with Anti-Inflammatory Properties.
Mol Pharm
; 15(12): 5809-5817, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30398879
2.
The First 50 Years of Molecular Pharmacology.
Mol Pharmacol
; 88(1): 139-40, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25943115
3.
EP2 receptor signaling pathways regulate classical activation of microglia.
J Biol Chem
; 288(13): 9293-302, 2013 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23404506
4.
When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?
Adv Exp Med Biol
; 813: 109-22, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25012371
5.
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
Proc Natl Acad Sci U S A
; 108(3): 1046-51, 2011 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21191102
6.
Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.
J Pharmacol Exp Ther
; 344(2): 360-7, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23192657
7.
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.
Proc Natl Acad Sci U S A
; 107(5): 2307-12, 2010 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080612
8.
Glutamate receptor ion channels: structure, regulation, and function.
Pharmacol Rev
; 62(3): 405-96, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20716669
9.
Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus.
Sci Rep
; 13(1): 5651, 2023 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37024553
10.
Phase 1 Clinical Results for NP10679, a pH-sensitive GluN2B-selective N-methyl-d-aspartate Receptor Inhibitor.
Clin Pharmacol Drug Dev
; 12(7): 706-717, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36642931
11.
Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
ACS Chem Neurosci
; 14(5): 917-935, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36779874
12.
Molecular cascades that mediate the influence of inflammation on epilepsy.
Epilepsia
; 52 Suppl 3: 33-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21542844
13.
Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin.
Epilepsia
; 51(9): 1714-20, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20345932
14.
Inhibition of the prostaglandin EP2 receptor prevents long-term cognitive impairment in a model of systemic inflammation.
Brain Behav Immun Health
; 8: 100132, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34589882
15.
An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors.
ACS Chem Neurosci
; 11(10): 1436-1446, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324375
16.
Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.
J Med Chem
; 63(3): 1032-1050, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904232
17.
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Bioorg Med Chem
; 17(17): 6463-80, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19648014
18.
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Neuropharmacology
; 149: 149-160, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30763657
19.
Avram Goldstein: the founder of molecular pharmacology.
Mol Pharmacol
; 83(4): 720-2, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23329728
20.
Why Is It so Hard to Do Good Science?
eNeuro
; 5(5)2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30197928