Detalhe da pesquisa
1.
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Cancer Res
; 61(24): 8758-68, 2001 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11751396
2.
P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes.
Biochem Pharmacol
; 62(6): 773-6, 2001 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11551523
3.
3,8-Diazabicyclo[3.2.1]octan-2-one peptide mimetics: synthesis of a conformationally restricted inhibitor of farnesyltransferase.
Org Lett
; 3(6): 865-8, 2001 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11263902
4.
Synthesis of conformationally constrained 5,6,7, 8-Tetrahydroimidazo[1,5-a]pyridine inhibitors of farnesyltransferase.
Org Lett
; 2(22): 3473-6, 2000 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-11082012
5.
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
Biofactors
; 6(3): 359-66, 1997.
Artigo
em Inglês
| MEDLINE | ID: mdl-9288406
6.
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
J Med Chem
; 42(19): 3779-84, 1999 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-10508426
7.
High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.
Anal Biochem
; 290(1): 126-37, 2001 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11180946
8.
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Bioorg Med Chem Lett
; 9(14): 1991-6, 1999 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-10450968
9.
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.
Bioorg Med Chem Lett
; 9(23): 3301-6, 1999 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-10612589
10.
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorg Med Chem Lett
; 11(11): 1411-5, 2001 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-11378366
11.
Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors.
J Biol Chem
; 276(27): 24457-65, 2001 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-11274181
12.
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.
Bioorg Med Chem Lett
; 11(7): 865-9, 2001 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-11294379
13.
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.
Bioorg Med Chem Lett
; 11(4): 537-40, 2001 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-11229765
14.
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
Bioorg Med Chem Lett
; 11(14): 1817-21, 2001 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-11459639
15.
Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.
J Am Chem Soc
; 123(9): 2107-8, 2001 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-11456854