Detalhe da pesquisa
1.
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.
Nature
; 605(7909): 340-348, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35344983
2.
Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities.
J Cell Mol Med
; 22(4): 2498-2509, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29441715
3.
Functionally impaired isoforms regulate TMPRSS6 proteolytic activity.
PLoS One
; 17(8): e0273825, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044454
4.
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice.
bioRxiv
; 2021 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972944
5.
Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature.
Expert Opin Ther Pat
; 30(11): 807-824, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32887532
6.
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
Cell Chem Biol
; 26(11): 1559-1572.e9, 2019 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31543462
7.
Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.
Sci Rep
; 8(1): 12562, 2018 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135444
8.
Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
PLoS One
; 12(7): e0180259, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28671992
9.
Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.
Eur J Med Chem
; 129: 110-123, 2017 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28219045