Detalhe da pesquisa
1.
An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.
PLoS Pathog
; 15(9): e1008065, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557263
2.
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Angew Chem Int Ed Engl
; 58(11): 3640-3644, 2019 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605929
3.
The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis.
Mol Microbiol
; 99(1): 172-87, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26374473
4.
The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism.
J Biol Chem
; 285(45): 35224-37, 2010 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20826822
5.
The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes.
Redox Biol
; 34: 101547, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32388269
6.
A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.
Redox Biol
; 15: 532-547, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29413965
7.
Catalytic properties, localization, and in vivo role of Px IV, a novel tryparedoxin peroxidase of Trypanosoma brucei.
Mol Biochem Parasitol
; 207(2): 84-8, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27262262
8.
Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.
ACS Med Chem Lett
; 7(12): 1073-1076, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994740
9.
Glutaredoxin-deficiency confers bloodstream Trypanosoma brucei with improved thermotolerance.
Mol Biochem Parasitol
; 204(2): 93-105, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854591
10.
Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase.
ChemMedChem
; 9(8): 1880-91, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24788386
11.
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.
Biochem Pharmacol
; 85(1): 38-45, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23085438
12.
Preparative enzymatic synthesis of trypanothione and trypanothione analogues.
Int J Parasitol
; 39(10): 1059-62, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19477177
13.
Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1.
Biol Chem
; 389(1): 21-32, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18095866
14.
Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes.
J Biol Chem
; 283(41): 27785-27798, 2008 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669638
15.
Glutathionylation of trypanosomal thiol redox proteins.
J Biol Chem
; 282(12): 8678-94, 2007 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17242409
16.
Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei.
J Biol Chem
; 280(15): 14385-94, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664987