Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review.

Considering the fundamental role of protein kinases in the mechanism of protein phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has underscored their therapeutic relevance. Imidazopyridines represent versatile scaffolds found in abundant bioactive compounds. Given their structural features, imidazopyridines have possessed pivotal potency to interact with different protein kinases, inspiring researchers to carry out numerous structural variations. In this comprehensive review, we encompass an extensive survey of the design and biological evaluations of imidazopyridine-based small molecules as potential agents targeting diverse kinases for anticancer applications. We describe the structural elements critical to inhibitory potency, elucidating their key structure-activity relationships (SAR) and mode of actions, where available. We classify these compounds into two groups: Serine/threonine and Tyrosine inhibitors. By highlighting the promising role of imidazopyridines in kinase inhibition, we aim to facilitate the design and development of more effective, targeted compounds for cancer treatment.

Body satisfaction and management in Iranian students.

PURPOSE: Despite the importance of body satisfaction on self concept and well being, there is little study about it or its consequences in Iranian populations, a part of Asian culture. The aim of this study was the assessment of body satisfaction and body management strategies in Iranian university students. WORK METHOD: This survey was performed based on a self-administrated questionnaire in 535 university and post graduate students. WORK RESULTS: About 2/3rd of the students had moderate to severe body dissatisfaction and 40% of the students were using body management methods. Rhinoplasty and heavy exercise were the most frequent body management methods in women and men, respectively. CONCLUSION: Widespread research on body satisfaction prevalence and its management behaviors in the general population can be effective in reducing the negative health, social and economic consequences of harmful behaviors.