Detalhe da pesquisa
1.
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
J Pharmacol Exp Ther
; 344(3): 686-95, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23275065
2.
In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Drug Metab Dispos
; 40(6): 1093-103, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22381334
3.
Development of oral extended release formulations of 6-hydroxybuspirone.
Biopharm Drug Dispos
; 33(9): 522-35, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23065950
4.
Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.
Depress Anxiety
; 27(5): 417-25, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20455246
5.
Disposition and metabolism of [14C]brasofensine in rats, monkeys, and humans.
Drug Metab Dispos
; 36(1): 24-35, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17908924
6.
Pharmacokinetics of a newly identified active metabolite of buspirone after administration of buspirone over its therapeutic dose range.
J Clin Pharmacol
; 46(11): 1308-12, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17050795
7.
Pre-absorption physicochemical compatibility assessment of 8-drug metabolic cocktail.
Int J Pharm
; 514(2): 364-373, 2016 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27291974
8.
Comparison of pharmacokinetics of lanoteplase and alteplase during acute myocardial infarction.
Clin Pharmacokinet
; 41(6): 445-52, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12074692
9.
Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers.
Clin Ther
; 34(3): 654-67, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22381714
10.
Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aß levels in healthy young men.
Clin Drug Investig
; 32(11): 761-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018285
11.
Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans.
Biopharm Drug Dispos
; 28(7): 393-402, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668416
12.
6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.
Drug Metab Dispos
; 35(8): 1387-92, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17494642
13.
Brasofensine treatment for Parkinson's disease in combination with levodopa/carbidopa.
Ann Pharmacother
; 36(2): 225-30, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11847938