Detalhe da pesquisa
1.
Rational design of balanced dual-targeting antibiotics with limited resistance.
PLoS Biol
; 18(10): e3000819, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33017402
2.
Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
Proc Natl Acad Sci U S A
; 115(25): E5726-E5735, 2018 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29871954
3.
Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.
Antimicrob Agents Chemother
; 63(9)2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235632
4.
Indispensability of Horizontally Transferred Genes and Its Impact on Bacterial Genome Streamlining.
Mol Biol Evol
; 33(5): 1257-69, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26769030
5.
Engineered ribosomal RNA operon copy-number variants of E. coli reveal the evolutionary trade-offs shaping rRNA operon number.
Nucleic Acids Res
; 43(3): 1783-94, 2015 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25618851
6.
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.
Nat Microbiol
; 8(3): 410-423, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36759752
7.
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Eur J Med Chem
; 213: 113200, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524686
8.
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.
Pharmaceutics
; 13(1)2020 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33374964
9.
Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity.
ChemMedChem
; 15(3): 265-269, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721445
10.
Second-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.
Future Med Chem
; 12(4): 277-297, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32043377
11.
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
Eur J Med Chem
; 167: 269-290, 2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30776691
12.
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
Eur J Med Chem
; 154: 117-132, 2018 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29778894
13.
Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis.
ACS Synth Biol
; 6(8): 1471-1483, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28426191