Detalhe da pesquisa
1.
How many kinases are druggable? A review of our current understanding.
Biochem J
; 480(16): 1331-1363, 2023 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37642371
2.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
EMBO J
; 38(20): e101443, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31424118
3.
LKB1 signaling and patient survival outcomes in hepatocellular carcinoma.
Pharmacol Res
; 192: 106757, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37023992
4.
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.
Mol Ther
; 30(1): 485-500, 2022 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450249
5.
NUAK family kinase 2 is a novel therapeutic target for prostate cancer.
Mol Carcinog
; 61(3): 334-345, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34818445
6.
Longitudinal Tibia Stress Fracture Risk During High-Volume Training: A Multiscale Modeling Pipeline Incorporating Bone Remodeling.
J Biomech Eng
; 144(10)2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35348634
7.
NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.
Breast Cancer Res Treat
; 189(1): 49-61, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34196902
8.
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Int J Mol Sci
; 22(2)2021 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33429995
9.
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors.
Molecules
; 26(19)2021 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34641454
10.
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Anticancer Drugs
; 31(8): 759-775, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32796402
11.
Concise, gram-scale synthesis of furo[2,3-b]pyridines with functional handles for chemoselective cross-coupling.
Tetrahedron Lett
; 61(38)2020 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33012852
12.
Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
Int J Mol Sci
; 21(21)2020 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33114754
13.
In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
Molecules
; 25(2)2020 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31941153
14.
Development and Comparison of Complementary Methods to Study Potential Skin and Inhalational Exposure to Pathogens During Personal Protective Equipment Doffing.
Clin Infect Dis
; 69(Suppl 3): S231-S240, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31517983
15.
Effect of an Intervention Package and Teamwork Training to Prevent Healthcare Personnel Self-contamination During Personal Protective Equipment Doffing.
Clin Infect Dis
; 69(Suppl 3): S248-S255, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31517976
16.
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.
Biochem J
; 475(15): 2435-2455, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934490
17.
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.
Biochem J
; 475(15): 2417-2433, 2018 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934491
18.
A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA.
J Biol Chem
; 292(41): 17037-17045, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821610
19.
In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with ß-Lactams To Inhibit Mycobacterial Growth.
Mol Pharm
; 15(11): 5410-5426, 2018 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30285456
20.
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Bioorg Med Chem Lett
; 28(10): 1958-1963, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653895