Detalhe da pesquisa
1.
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Chem Res Toxicol
; 37(1): 57-71, 2024 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177062
2.
Comparative genomics of the medicinal plants Lonicera macranthoides and L. japonica provides insight into genus genome evolution and hederagenin-based saponin biosynthesis.
Plant Biotechnol J
; 21(11): 2209-2223, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37449344
3.
Baohuoside I inhibits FXR signaling pathway to interfere with bile acid homeostasis via targeting ER α degradation.
Cell Biol Toxicol
; 39(4): 1215-1235, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35802278
4.
[Advance in biosynthesis and metabolic regulation of ginkgolides].
Zhongguo Zhong Yao Za Zhi
; 46(13): 3288-3297, 2021 Jul.
Artigo
em Chinês
| MEDLINE | ID: mdl-34396747
5.
Comparative analysis and natural evolution of squalene epoxidase in three Fritillaria species.
Plant Mol Biol
; 103(6): 705-718, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32577984
6.
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg Med Chem
; 27(3): 457-469, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30606676
7.
Comprehensive analysis of JAZ family members in Ginkgo biloba reveals the regulatory role of the GbCOI1/GbJAZs/GbMYC2 module in ginkgolide biosynthesis.
Tree Physiol
; 44(1)2024 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37741055
8.
Ultrasensitive upconverting nanoprobes for in situ imaging of drug-induced liver injury using miR-122 as the biomarker.
Talanta
; 274: 126108, 2024 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38640602
9.
Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J Virol
; 86(12): 6503-11, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496223
10.
An integrated strategy combining network toxicology and feature-based molecular networking for exploring hepatotoxic constituents and mechanism of Epimedii Folium-induced hepatotoxicity in vitro.
Food Chem Toxicol
; 176: 113785, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080529
11.
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Antimicrob Agents Chemother
; 56(7): 3767-75, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526308
12.
ß-D-2'-α-F-2'-ß-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Bioorg Med Chem Lett
; 22(18): 5924-9, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892115
13.
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methylguanosine.
Antimicrob Agents Chemother
; 55(6): 2566-75, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21444700
14.
Integrative Omics Analyses Reveal the Effects of Copper Ions on Salvianolic Acid Biosynthesis.
Front Plant Sci
; 12: 746117, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34745177
15.
A novel method for ginkgolide biosynthesis elucidation based on MeJA induction and differential metabolomics.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1176: 122758, 2021 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34052558
16.
Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
J Med Chem
; 64(2): 925-937, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459024
17.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Bioorg Med Chem Lett
; 20(15): 4539-43, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20580554
18.
2'-deoxy-2'-α-fluoro-2'-ß-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorg Med Chem Lett
; 20(24): 7376-80, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21050754
19.
Comparative transcriptome analysis of MeJA-responsive AP2/ERF transcription factors involved in notoginsenosides biosynthesis.
3 Biotech
; 10(7): 290, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550109
20.
A Randomized, Open-Label, Controlled Clinical Trial of Azvudine Tablets in the Treatment of Mild and Common COVID-19, a Pilot Study.
Adv Sci (Weinh)
; 7(19): e2001435, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35403380