Detalhe da pesquisa
1.
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.
Nature
; 621(7980): 840-848, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37674084
2.
A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.
Immunity
; 50(4): 1043-1053.e5, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902636
3.
Characterization of AST-001 non-clinical pharmacokinetics: A novel selective AKR1C3-activated prodrug in mice, rats, and cynomolgus monkeys.
Biopharm Drug Dispos
; 45(2): 83-92, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38492211
4.
Improving the Accuracy of Protein Thermostability Predictions for Single Point Mutations.
Biophys J
; 119(1): 115-127, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32533939
5.
Exploring conformational search protocols for ligand-based virtual screening and 3-D QSAR modeling.
J Comput Aided Mol Des
; 29(2): 165-82, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25408244
6.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712280
7.
Erratum: A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity.
Am J Cancer Res
; 13(11): 5750, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38058837
8.
The In-Vitro Antitumor Effects of AST-3424 Monotherapy and Combination Therapy With Oxaliplatin or 5-Fluorouracil in Primary Liver Cancer.
Front Oncol
; 12: 885139, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35936728
9.
A novel selective AKR1C3-activated prodrug AST-3424/OBI-3424 exhibits broad anti-tumor activity.
Am J Cancer Res
; 11(7): 3645-3659, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34354865
10.
Understanding the molecular activity of alkaline sphingomyelinase (NPP7) by computer modeling.
Biochemistry
; 49(42): 9096-105, 2010 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20839774
11.
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.
Bioorg Med Chem
; 18(10): 3518-34, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20430628
12.
Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer.
Clin Cancer Res
; 30(10): 2287, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38745478
13.
OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.
Clin Cancer Res
; 25(14): 4493-4503, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31015346
14.
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
J Med Chem
; 51(8): 2412-20, 2008 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18257544
15.
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Cancer Chemother Pharmacol
; 61(6): 953-63, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17639393
16.
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
J Med Chem
; 50(5): 1001-6, 2007 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17286393
17.
Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability-Large-Scale Validation of MD-Based Relative Free Energy Calculations.
J Mol Biol
; 429(7): 948-963, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27964946
18.
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal
; 10(505)2017 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29138295
19.
AutoQSAR: an automated machine learning tool for best-practice quantitative structure-activity relationship modeling.
Future Med Chem
; 8(15): 1825-1839, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27643715
20.
Thermal unfolding simulations of a multimeric protein--transition state and unfolding pathways.
Proteins
; 59(2): 170-82, 2005 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15723359