Detalhe da pesquisa
1.
Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors.
Bioorg Med Chem Lett
; 30(11): 127149, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32247731
2.
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Bioorg Chem
; 96: 103643, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32035298
3.
Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.
Bioorg Chem
; 103: 104184, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891861
4.
Dibenzocyclooctynes: Effect of Aryl Substitution on Their Reactivity toward Strain-Promoted Alkyne-Azide Cycloaddition.
J Org Chem
; 84(13): 8542-8551, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199143
5.
Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors.
Org Biomol Chem
; 17(10): 2798-2808, 2019 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30793727
6.
Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.
Arch Pharm (Weinheim)
; 352(5): e1800227, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30947375
7.
One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.
J Org Chem
; 83(24): 15323-15332, 2018 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30520637
8.
Iodine(III)-mediated halogenations of acyclic monoterpenoids.
Beilstein J Org Chem
; 14: 1103-1111, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29977382
9.
On the discovery of new potent human farnesyltransferase inhibitors: emerging pyroglutamic derivatives.
Org Biomol Chem
; 15(38): 8110-8118, 2017 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28905970
10.
Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.
Bioorg Med Chem
; 25(16): 4433-4443, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28666857
11.
New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation.
Bioorg Med Chem Lett
; 26(15): 3730-4, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282741
12.
Methylene versus carbonyl bridge in the structure of new tubulin polymerization inhibitors with tricyclic A-rings.
Bioorg Med Chem
; 24(22): 6021-6030, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707624
13.
Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.
Bioorg Med Chem
; 24(10): 2307-17, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073050
14.
Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors.
Bioorg Med Chem
; 24(14): 3102-7, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27240468
15.
Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events.
Bioorg Med Chem Lett
; 25(18): 3975-9, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26227778
16.
Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.
Bioorg Med Chem Lett
; 25(20): 4447-52, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372651
17.
Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B.
Mar Drugs
; 13(8): 5102-10, 2015 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26266415
18.
Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.
Bioorg Med Chem Lett
; 24(24): 5777-5781, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453818
19.
Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.
Bioorg Med Chem Lett
; 24(14): 3180-5, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24856060
20.
Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors.
Bioorg Med Chem Lett
; 23(21): 5887-92, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24054122