Fused silica ablation by double ultrashort laser pulses with dual wavelength and variable delays.

Today, glass and other similar dielectric materials are widely used in modern manufacturing. However, glass is a brittle and a heat sensitive material. Laser technology is used to process glass but quality and throughput are still a key issue. In the present paper, we investigate dual-wavelength double ultrashort laser pulses in order to control free electrons dynamics and subsequent ablation for fused silica processing, and further improve the understanding of this laser-material interaction. We used a high average power Yb-doped femtosecond laser source (100 W) with two optical lines exhibiting different pulse durations and wavelengths (500 fs at 515 nm; and 1 or 10 ps at 1030 nm) with various fluences and delays. The best configuration in terms of ablation efficiency is expected to take place when the green pulse first induces free electrons, followed by their heating by the red pulse. The obtained results are discussed in terms of optical transmission as well as ablated volume, and are compared with single pulse ablation. Our experimental results are supported by absorbed energy density calculations based on a model considering the two-color laser induced electron dynamics, including photoionization, laser heating of free electrons, and their recombination. We demonstrate that there is an optimal cooperating effect between the two sub-pulses for a 1-ps delay, nevertheless there is no beneficial effect in splitting the beam for optimizing fused silica ablation compared with the single-pulse green configuration.

Ultrashort laser induced spatial redistribution of silver species and nano-patterning of etching selectivity in silver-containing glasses.

Femtosecond laser-induced spatial redistribution of silver species (ions, clusters, and hole centers) in a silver-containing phosphate glass is investigated by correlative means of near-field scanning optical microscopy (NSOM) images, numerical simulations, chemical micro-probe analysis, and nanoscale spatial profiles after soft etching. In particular, we found that the chemical etching selectivity for nanoscale patterning is strongly dependent upon the irradiation of femtosecond laser due to the spatial redistribution of silver species within the affected area. These results strongly indicate that controlling the distribution of silver species by femtosecond laser irradiation may open new routes for surface nanoscale chemical and/or spatial patterning for the fabrication of 2D surface photonic crystals.

Laser writing of nonlinear optical properties in silver-doped phosphate glass.

The formation of both local second- and third-harmonic generations (SHG and THG) induced by a train of femtosecond laser pulses in silver-doped phosphate glasses is addressed. Based on modeling calculations, including various diffusion and kinetic processes, THG is shown to result from the formation of silver clusters. The latter organize into a ring-shape structure, leading to the emergence of a static electric field. By breaking the glass centro-symmetry, this field gives rise to a local effective second-order susceptibility, inducing SHG. Both theoretically predicted SHG and THG evolutions with respect to the number of pulses in the train are in good agreement with experimental observations. In particular, the observed reaching of a maximum in the nonlinear optical responses after a few thousands of pulses is explained by the competition of various physical processes. A cooling of the glass is shown to improve the process efficiency of the laser writing of second-order nonlinearity.

Experimental Investigation of the Collective Raman Scattering of Multiple Laser Beams in Inhomogeneous Plasmas.

Experiments have been performed evidencing significant stimulated Raman sidescattering (SRS) at large angles from the density gradient. This was achieved in long scale-length high-temperature plasmas in which two beams couple to the same scattered electromagnetic wave further demonstrating for the first time this multiple-beam collective SRS interaction. The collective nature of the coupling and the amplification at large angles from the density gradient increase the global SRS losses and produce light scattered in novel directions out of the planes of incidence of the beams. These findings obtained in plasmas conditions relevant of inertial confinement fusion experiments similarly apply to the more complex geometry of these experiments where anomalously large levels of SRS were measured.

Improved modeling of the solid-to-plasma transition of polystyrene ablator for laser direct-drive inertial confinement fusion hydrocodes.

The target performance of laser direct-drive inertial confinement fusion (ICF) can be limited by the development of hydrodynamic instabilities resulting from the nonhomegeneous laser absorption at the target surface, i.e., the laser imprint on the ablator. To understand and describe the formation of these instabilities, the early ablator evolution during the laser irradiation should be considered. In this work, an improved modeling of the solid-to-plasma transition of a polystyrene ablator for laser direct-drive ICF is proposed. This model is devoted to be implemented in hydrocodes dedicated to ICF which generally assume an initial plasma state. The present approach consists of the two-temperature model coupled to the electron, ion and neutral dynamics including the chemical fragmentation of polystyrene. The solid-to-plasma transition is shown to significantly influence the temporal evolution of both free electron density and temperatures, which can lead to different shock formation and propagation compared with an initial plasma state. The influence of the solid-to-plasma transition on the shock dynamics is evidenced by considering the scaling law of the pressure with respect to the laser intensity. The ablator transition is shown to modify the scaling law exponent compared with an initial plasma state.

Implementing a microphysics model in hydrodynamic simulations to study the initial plasma formation in dielectric ablator materials for direct-drive implosions.

A microphysics model to describe the photoionization and impact ionization processes in dielectric ablator materials like plastic has been implemented into the one-dimensional hydrodynamic code LILAC for planar and spherical targets. At present, the initial plasma formation during the early stages of a laser drive are modeled in an ad hoc manner, until the formation of a critical surface. Implementation of the physics-based models predict higher values of electron temperature and pressure than the ad hoc model. Moreover, the numerical predictions are consistent with previous experimental observations of the shinethrough mechanism in plastic ablators. For planar targets, a decompression of the rear end of the target was observed that is similar to recent experiments. An application of this model is to understand the laser-imprint mechanism that is caused by nonuniform laser irradiation due to single beam speckle.

Optical Bloch modeling of femtosecond-laser-induced electron dynamics in dielectrics.

A model based on optical Bloch equations is developed to describe the interaction of femtosecond laser pulses with dielectric solids, accounting for optical-cycle-resolved electron dynamics. It includes the main physical processes at play: photoionization, impact ionization, direct and collisional laser heating, and recombination. By using an electron band structure, this approach also accounts for material optical properties as nonlinear polarization response. Various studies are performed, shedding light on the contribution of various processes to the full electron dynamics depending on laser intensity and wavelength. In particular, the standard influence of the impact ionization process is retrieved.

Direct-drive measurements of laser-imprint-induced shock velocity nonuniformities.

Perturbations in the velocity profile of a laser-ablation-driven shock wave seeded by speckle in the spatial beam intensity (i.e., laser imprint) have been measured. Direct measurements of these velocity perturbations were recorded using a two-dimensional high-resolution velocimeter probing plastic material shocked by a 100-ps picket laser pulse from the OMEGA laser system. The measured results for experiments with one, two, and five overlapping beams incident on the target clearly demonstrate a reduction in long-wavelength (>25-µm) perturbations with an increasing number of overlapping laser beams, consistent with theoretical expectations. These experimental measurements are crucial to validate radiation-hydrodynamics simulations of laser imprint for laser direct drive inertial confinement fusion research since they highlight the significant (factor of 3) underestimation of the level of seeded perturbation when the microphysics processes for initial plasma formation, such as multiphoton ionization are neglected.

Modeling the solid-to-plasma transition for laser imprinting in direct-drive inertial confinement fusion.

Laser imprinting possesses a potential danger for low-adiabat and high-convergence implosions in direct-drive inertial confinement fusion (ICF). Within certain direct-drive ICF schemes, a laser picket (prepulse) is used to condition the target to increase the interaction efficiency with the main pulse. Whereas initially the target is in a solid state (of ablators such as polystyrene) with specific electronic and optical properties, the current state-of-the-art hydrocodes assume an initial plasma state, which ignores the detailed plasma formation process. To overcome this strong assumption, a model describing the solid-to-plasma transition, eventually aiming at being implemented in hydrocodes, is developed. It describes the evolution of main physical quantities of interest, including the free electron density, collision frequency, absorbed laser energy, temperatures, and pressure, during the first stage of the laser-matter interaction. The results show that a time about 100 ps is required for the matter to undergo the phase transition, the initial solid state thus having a notable impact on the subsequent plasma dynamics. The nonlinear absorption processes (associated to the solid state) are also shown to have an influence on the thermodynamic quantities after the phase transition, leading to target deformations depending on the initial solid state. The negative consequences for the ICF schemes consist in shearing of the ablator and possibly preliminary heating of the deuterium-tritium fuel.

Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols.

OBJECTIVE: To test the dose-response effect on low-density lipoprotein cholesterol (LDL-c) of plant sterols (PS) from different sources in a low-fat spread. METHODS: Dose responses of soybean oil (BO), tall oil (TO) and a mix of tall oil and rapeseed oil (TO/RP) as fatty acid esters were tested in a parallel design in free-living subjects recruited from the general community who had elevated cholesterol concentrations. Subjects received either control for 6 weeks or 1.6 g PS per day for 3 weeks, then 3.0 g/day for 3 weeks. RESULTS: LDL-c was lowered significantly by consumption of 1.6 g/day of PS (-10.4%, range -7.3 to -11.4%). Increasing the dose to 3.0 g/day modestly reduced LDL-c concentrations further to -14.7%. TO, containing 78% sitosterol, produced an increase in serum sitosterol of 6.5 nmol/ml, while BO, containing only 27% campesterol, produced an increase in serum campesterol of 9.5 nmol/ml in 6 weeks. After PS withdrawal, serum sterols declined by 50% within 2 weeks. CONCLUSION: Different PS sources were equally effective in lowering serum LDL-c concentrations. The decrease in absolute concentrations of LDL-c was dependent on the baseline concentrations.

Preferential efflux of phytosterols over cholesterol from macrophages.

Phytosterols are structurally similar to cholesterol. Increased dietary intake of phytosterols effectively lowers LDL-cholesterol. Since phytosterols are incorporated in a growing number of foods and some of the ingested phytosterols reach the circulation, accumulation of phytosterols in foam-cell-prone cells such as macrophages might occur. Therefore we examined the influx and efflux of phytosterols by human THP-1 macrophages. The influx rates of methyl-beta-cyclodextrin delivered phytosterols did not significantly differ from that of cholesterol (approximately 3.8 pmol/min per mg cellular protein), neither did the total influx of oxidised LDL delivered phytosterols differ from that of cholesterol. The efflux of beta-sitosterol and sitostanol from preloaded THP-1 cells to HDL was more efficient than the efflux of campesterol and cholesterol (rate constants of 0.41 +/- 0.04/h, 0.62 +/- 0.08/h, 0.23 +/- 0.05/h and 0.29 +/- 0.03/h, respectively). The efflux of beta-sitosterol was not associated with a dominant transfer to ApoA-I, nor did ABCA1 induction-promoted cholesterol efflux to the level observed for beta-sitosterol. Our data show that THP-1 macrophages take up phytosterols, but have efficient mechanisms to remove phytosterols from their cellular compartments. Consequently, it is less likely that macrophages preferentially accumulate phytosterols over cholesterol and hence promote foam-cell formation in vivo.

Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects.

OBJECTIVE: To determine the impact of intake occasion (with or without a meal), and product fat level on the cholesterol-lowering efficacy of a plant sterol (PS)-enriched (3 g/day) single-dose yoghurt drink. DESIGN: Double-blind, randomized, placebo-controlled, parallel study with a 4 weeks run-in and 4 weeks intervention period. SETTING: Subjects recruited from the general community. SUBJECTS: A total of 184 moderate hypercholesterolaemic subjects (81 men and 103 women) (age 57+/-2 years) completed the study. INTERVENTIONS: The study product was a 100-g single-dose yoghurt drink with or without added PS in the form of PS esters. The subjects were randomly assigned to one of five 4-week treatments: (i) drink A (0.1% dairy fat, 2.2% total fat) with a meal, (ii) drink A without a meal, (iii) drink B (1.5% dairy fat, 3.3% total fat) with a meal, (iv) drink B without a meal and (v) placebo drink with a meal. RESULTS: LDL-cholesterol (LDL-C) was significantly lowered when the single-dose drink was taken with a meal independent of its fat content (drink A: -9.5% (P<0.001, 95% CI: -13.8 to -5.2); drink B: -9.3% (P<0.001, 95% CI: -13.7 to -4.9)) as compared to placebo. When consumed without a meal, LDL-C was also significantly decreased (drink A: -5.1% (P<0.05, 95% CI: -9.4 to -0.8); drink B: -6.9% (P<0.01, 95% CI: -11.3 to -2.5) as compared to placebo, however the effect was significantly smaller as compared to the intake with a meal. CONCLUSION: These results indicate that a PS-ester-enriched single-dose yoghurt drink effectively reduces LDL-C irrespective of the fat content of the product. A substantially larger decrease in serum cholesterol concentration was achieved when the single-dose drink was consumed with a meal emphasizing the importance of the intake occasion for optimal cholesterol-lowering efficacy. SPONSORSHIP: Unilever Research and Development, Vlaardingen, The Netherlands.

Enhanced photoemission from laser-excited plasmonic nano-objects in periodic arrays.

The process of photoelectron emission from gold surfaces covered with nano-objects that are organized in the form of a periodic array is addressed in the short laser pulse regime ([Formula: see text] fs) at moderate intensities [Formula: see text] W cm(-2) and for various laser wavelengths. The emission spectrum from a gold single crystal measured under the same conditions is used for reference. The comparison of the photo-emission yield and the energy of the ejected electrons with their counterparts from the (more simple) reference system shows that the periodic conditions imposed on the target surface drastically enhance both quantities. In addition to the standard mechanism of Coulomb explosion, a second mechanism comes into play, driven by surface plasmon excitation. This can be clearly demonstrated by varying the laser wavelength. This interpretation of the experimental data is supported by predictions from model calculations that account both for the primary quantum electron emission and for the subsequent surface-plasmon-driven acceleration in the vacuum. Despite the fact that the incident laser intensity is as low as [Formula: see text] W cm(-2), such a structured target permits generating electrons with energies as high as 300 eV. Experiments with two incident laser beams of different wavelengths with an adjustable delay, have also been carried out. The results show that there exist various channels for the decay of the photo-emission signal, depending on the target type. These observations are shedding light on the various relaxation mechanisms that take place on different timescales.

Modeling of the cross-beam energy transfer with realistic inertial-confinement-fusion beams in a large-scale hydrocode.

A method for modeling realistic laser beams smoothed by kinoform phase plates is presented. The ray-based paraxial complex geometrical optics (PCGO) model with Gaussian thick rays allows one to create intensity variations, or pseudospeckles, that reproduce the beam envelope, contrast, and high-intensity statistics predicted by paraxial laser propagation codes. A steady-state cross-beam energy-transfer (CBET) model is implemented in a large-scale radiative hydrocode based on the PCGO model. It is used in conjunction with the realistic beam modeling technique to study the effects of CBET between coplanar laser beams on the target implosion. The pseudospeckle pattern imposed by PCGO produces modulations in the irradiation field and the shell implosion pressure. Cross-beam energy transfer between beams at 20(∘) and 40(∘) significantly degrades the irradiation symmetry by amplifying low-frequency modes and reducing the laser-capsule coupling efficiency, ultimately leading to large modulations of the shell areal density and lower convergence ratios. These results highlight the role of laser-plasma interaction and its influence on the implosion dynamics.

Coupled hydrodynamic model for laser-plasma interaction and hot electron generation.

We present a formulation of the model of laser-plasma interaction (LPI) at hydrodynamical scales that couples the plasma dynamics with linear and nonlinear LPI processes, including the creation and propagation of high-energy electrons excited by parametric instabilities and collective effects. This formulation accounts for laser beam refraction and diffraction, energy absorption due to collisional and resonant processes, and hot electron generation due to the stimulated Raman scattering, two-plasmon decay, and resonant absorption processes. Hot electron (HE) transport and absorption are described within the multigroup angular scattering approximation, adapted for transversally Gaussian electron beams. This multiscale inline LPI-HE model is used to interpret several shock ignition experiments, highlighting the importance of target preheating by HEs and the shortcomings of standard geometrical optics when modeling the propagation and absorption of intense laser pulses. It is found that HEs from parametric instabilities significantly increase the shock pressure and velocity in the target, while decreasing its strength and the overall ablation pressure.

Correlation between nasal ciliary beat frequency and mucus transport rate in volunteers.

The correlation between mucus transport time (MTT) and nasal ciliary beat frequency (CBF) in human volunteers was investigated. Mucus transport was measured with the indigo carmine/saccharin sodium test. The test can be performed easily, with no need for sophisticated equipment. CBF was measured photometrically in biopsies from the ciliated epithelium of the nose. After statistical analysis with the Shapiro-Wilk test, it appeared that the logarithms of the MTTs were distributed normally. The correlation between the CBF and the log-MTT was tested with the least-square method. Correlation coefficients are r = -0.55 and r = -0.51 (n = 31) for the log-MTTs as measured with saccharin sodium and indigo carmine respectively. The results are significant at a level alpha = 0.005. The highly significant correlation between CBF and log-MTT suggests that CBF is the main factor in the nasal mucociliary clearance in healthy volunteers. The indigo carmine/saccharin sodium test appears to be useful in testing the in vivo effects of nasal drugs on mucociliary clearance.

Towards modeling of nonlinear laser-plasma interactions with hydrocodes: the thick-ray approach.

This paper deals with the computation of laser beam intensity in large-scale radiative hydrocodes applied to the modeling of nonlinear laser-plasma interactions (LPIs) in inertial confinement fusion (ICF). The paraxial complex geometrical optics (PCGO) is adapted for light waves in an inhomogeneous medium and modified to include the inverse bremsstrahlung absorption and the ponderomotive force. This thick-ray model is compared to the standard ray-tracing (RT) approach, both in the chic code. The PCGO model leads to different power deposition patterns and better diffraction modeling compared to standard RT codes. The intensity-reconstruction technique used in RT codes to model nonlinear LPI leads to artificial filamentation and fails to reproduce realistic ponderomotive self-focusing distances, intensity amplifications, and density channel depletions, whereas PCGO succeeds. Bundles of Gaussian thick rays can be used to model realistic non-Gaussian ICF beams. The PCGO approach is expected to improve the accuracy of ICF simulations and serve as a basis to implement diverse LPI effects in large-scale hydrocodes.

Helicobacter pylori infection does not influence the efficacy of iron and vitamin B(12) fortification in marginally nourished Indian children.

BACKGROUND/OBJECTIVES: Helicobacter pylori infection and iron and vitamin B(12) deficiencies are widespread in economically disadvantaged populations. There is emerging evidence that H. pylori infection has a negative effect on the absorption of these micronutrients. The aim of this study was to evaluate the effect of H. pylori infection on the efficacy of micronutrient (including iron and vitamin B(12))-fortified foods supplied for 1 year in marginally nourished children. SUBJECTS/METHODS: In all, 543 Indian children, aged 6-10 years, participated in a double-blind, randomized controlled intervention trial, receiving foods fortified with either high (100% Recommended Dietary Allowances (RDA)) or low (15% RDA) amounts of iron, vitamin B(12) and other micronutrients. The presence of H. pylori infection was diagnosed by the (13)C-labeled urea breath test at 11 months after the start of the intervention. Blood hemoglobin, serum ferritin (SF), total body iron and plasma vitamin B(12) were estimated at baseline and 12 months, and differences between these time points were assessed using an independent t-test. RESULTS: Overall, the prevalence of H. pylori infection in this group of children was 79%. Baseline hemoglobin, SF, body iron and vitamin B(12) concentrations were not associated with H. pylori infection. The response to the intervention (either high or low amounts of iron and vitamin B(12) fortification) in terms of change in iron markers and vitamin B(12) status did not differ between children with and without H. pylori infection. CONCLUSIONS: This study shows that the presence of H. pylori infection did not affect the efficacy of long-term iron and vitamin B(12) fortification in these marginally nourished children.

Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters.

INTRODUCTION: The omega-3 fatty acid docosahexaenoic acid (DHA) accounts for 10% of fatty acids in human brain and is critical for neuronal function and brain development. Mechanisms of transport, accumulation and conservation of DHA in the brain are unclear. The objective of the study was to quantify the age dependent DHA incorporation into the brain of 2-, 4- or 10-week-old rats after a bolus dose of different DHA-esters. METHODS: Rats were gavaged with (14)C-DHA-TAG, (14)C-DHA-PL or (14)C-DHA-TAG+PL at 2 mg DHA/kg BW. After 24h the distribution of radioactivity in body and brain regions was determined using quantitative whole body autoradiography (QWBA). Radiolabeled compounds were extracted from the brains to determine the identity of the radiolabeled compounds. RESULTS: Accumulation of orally ingested (14)C-DHA in rat brain was less than 1% of the dose and decreased with age. Ester specific differences were seen only in 10-week-old rats, where oral (14)C-DHA-PL delivered a 2-fold higher accretion of radioactivity in the brain. CONCLUSIONS: Less than 1% of a dietary achievable DHA dose reached the rat brain within 24h. Optimal efficacy of DHA-PL may occur in older age groups.

Postprandial evolution in composition and characteristics of human duodenal fluids in different nutritional states.

The purpose of this study was to assess the changes in duodenal composition in three nutritional states: fasted, fed, and fat-enriched fed state. Two isocaloric meals were administered to healthy subjects on nonconsecutive days. Subsequently, duodenal samples were collected every 30 min after which they were characterized with respect to pH, lipolytic products, bile salts, phospholipids, osmolality, and surface tension. The resulting time profiles displayed fluctuating patterns, which reflect high inter- and intrasubject variability. Duodenal composition was not altered by the higher fat percentage of the fat-enriched liquid meal. Monoglycerides, amounting from 5% to 88% of total lipids, were the dominant lipolytic species, followed by free fatty acids. Within 30 min after meal administration, individual intraduodenal concentrations of lipid products were 0.0-5.5, 1.0-14.9, and 3.1-22.4 mg/mL in fasted, fed, and fat-enriched fed state, respectively. The corresponding values for bile salts were 2.0-9.0, 6.9-9.3, and 4.4-30.3 mM and for phospholipids 0.06-2.4, 2.6-5.7, and 1.4-9.3 mM, respectively. Specific trends though, were not detected. This study illustrates the variable intraluminal conditions that can result after food intake. As intraduodenal events (e.g., intraduodenal dissolution) affect absorption of poorly water soluble and/or highly lipophilic drugs, this variability may possibly contribute to the highly variable drug plasma-time profiles often observed.