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1.
Nature ; 495(7440): 187-92, 2013 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-23486058

RESUMO

Magnetic resonance is an exceptionally powerful and versatile measurement technique. The basic structure of a magnetic resonance experiment has remained largely unchanged for almost 50 years, being mainly restricted to the qualitative probing of only a limited set of the properties that can in principle be accessed by this technique. Here we introduce an approach to data acquisition, post-processing and visualization--which we term 'magnetic resonance fingerprinting' (MRF)--that permits the simultaneous non-invasive quantification of multiple important properties of a material or tissue. MRF thus provides an alternative way to quantitatively detect and analyse complex changes that can represent physical alterations of a substance or early indicators of disease. MRF can also be used to identify the presence of a specific target material or tissue, which will increase the sensitivity, specificity and speed of a magnetic resonance study, and potentially lead to new diagnostic testing methodologies. When paired with an appropriate pattern-recognition algorithm, MRF inherently suppresses measurement errors and can thus improve measurement accuracy.


Assuntos
Testes Diagnósticos de Rotina/métodos , Espectroscopia de Ressonância Magnética/métodos , Algoritmos , Humanos , Movimento (Física) , Reconhecimento Automatizado de Padrão , Imagens de Fantasmas , Reprodutibilidade dos Testes , Projetos de Pesquisa , Sensibilidade e Especificidade
2.
Magn Reson Med ; 73(2): 711-7, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24639034

RESUMO

PURPOSE: The Dixon techniques provide uniform water-fat separation but require multiple image sets, which extend the overall acquisition time. Here, an alternative rapid single acquisition method, lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA), was introduced. METHODS: The LEENA method utilized a fast imaging with steady-state free precession sequence to obtain a single k-space dataset in which successive k-space lines are acquired to allow the fat magnetization to precess 180°. The LEENA data were then unghosted using either image-domain (LEENA-S) or k-space domain (LEENA-G) parallel imaging techniques to reconstruct water-only and fat-only images. An off-resonance correction technique was incorporated to improve the uniformity of the water-fat separation. RESULTS: Uniform water-fat separation was achieved for both the LEENA-S and LEENA-G methods for phantom and human body and leg imaging applications at 1.5T and 3T. The resultant water and fat images were qualitatively similar to conventional 2-point Dixon and fat-suppressed images. CONCLUSION: The LEENA-S and LEENA-G methods provide uniform water and fat images from a single MRI acquisition. These straightforward methods can be adapted to 1.5T and 3T clinical MRI scanners and provide comparable fat/water separation with conventional 2-point Dixon and fat-suppression techniques.


Assuntos
Tecido Adiposo/anatomia & histologia , Artefatos , Aumento da Imagem/métodos , Lipídeos/análise , Imageamento por Ressonância Magnética/métodos , Técnica de Subtração , Algoritmos , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Reconhecimento Automatizado de Padrão/métodos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
3.
Magn Reson Med ; 71(6): 2243-9, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23900921

RESUMO

PURPOSE: A prototype wireless guidance device using single sideband amplitude modulation (SSB) is presented for a 1.5T magnetic resonance imaging system. METHODS: The device contained three fiducial markers each mounted to an independent receiver coil equipped with wireless SSB technology. Acquiring orthogonal projections of these markers determined the position and orientation of the device, which was used to define the scan plane for a subsequent image acquisition. Device localization and scan plane update required approximately 30 ms, so it could be interleaved with high temporal resolution imaging. Since the wireless device is used for localization and does not require full imaging capability, the design of the SSB wireless system was simplified by allowing an asynchronous clock between the transmitter and receiver. RESULTS: When coupled to a high readout bandwidth, the error caused by the lack of a shared frequency reference was quantified to be less than one pixel (0.78 mm) in the projection acquisitions. Image guidance with the prototype was demonstrated with a phantom where a needle was successfully guided to a target and contrast was delivered. CONCLUSION: The feasibility of active tracking with a wireless detector array is demonstrated. Wireless arrays could be incorporated into devices to assist in image-guided procedures.


Assuntos
Marcadores Fiduciais , Imageamento por Ressonância Magnética/instrumentação , Tecnologia sem Fio , Desenho de Equipamento , Estudos de Viabilidade , Imagens de Fantasmas
4.
Magn Reson Med ; 68(2): 421-9, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22131264

RESUMO

Resolution enhanced T(1)-insensitive steady-state imaging (RE-TOSSI) is a new MRI pulse sequence for the generation of rapid T(2) contrast with high spatial resolution. TOSSI provides T(2) contrast by using nonequally spaced inversion pulses throughout a balanced steady-state free precession (SSFP) acquisition. In RE-TOSSI, these energy and time intensive adiabatic inversion pulses and associated magnetization preparation are removed from TOSSI after acquisition of the data around the center of k-space. Magnetization evolution simulations demonstrate T(2) contrast in TOSSI as well as reduction in the widening of the point spread function width (by up to a factor of 4) to a near ideal case for RE-TOSSI. Phantom experimentation is used to characterize and compare the contrast and spatial resolution properties of TOSSI, RE-TOSSI, balanced SSFP, Half-Fourier Acquisition Single-Shot Turbo Spin Echo (HASTE), and turbo spin echo and to optimize the fraction of k-space acquired using TOSSI. Comparison images in the abdomen and brain demonstrate similar contrast and improved spatial resolution in RE-TOSSI compared with TOSSI; comparison balanced SSFP, HASTE, and turbo spin echo images are provided. RE-TOSSI is capable of providing high spatial resolution T(2)-weighted images in 1 s or less per image.


Assuntos
Algoritmos , Encéfalo/anatomia & histologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Processamento de Sinais Assistido por Computador , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
5.
Magn Reson Med ; 68(2): 631-8, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22247080

RESUMO

Multichannel transmission has the potential to improve many aspects of MRI through a new paradigm in excitation. In this study, multichannel transmission is used to address the effects that variations in B(0) homogeneity have on fat-saturation preparation through the use of the frequency, phase, and amplitude degrees of freedom afforded by independent transmission channels. B(1) homogeneity is intrinsically included via use of coil sensitivities in calculations. A new method, parallel excitation for B-field insensitive fat-saturation preparation, can achieve fat saturation in 89% of voxels with M(z) ≤ 0.1 in the presence of ± 4 ppm B(0) variation, where traditional CHESS methods achieve only 40% in the same conditions. While there has been much progress to apply multichannel transmission at high field strengths, particular focus is given here to application of these methods at 1.5 T.


Assuntos
Tecido Adiposo/anatomia & histologia , Aumento da Imagem/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Modelos Biológicos , Desenho de Equipamento , Análise de Falha de Equipamento , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
6.
Magn Reson Med ; 65(6): 1630-7, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21287592

RESUMO

Multislice parallel imaging involves the simultaneous sampling of multiple parallel slices which are subsequently separated using parallel imaging reconstruction. The CAIPIRINHA technique improves this reconstruction by manipulating the phase of the RF excitation pulses to shift the aliasing pattern such that there is less aliasing energy to be reconstructed. In this work, it is shown that combining the phase manipulation used in CAIPIRINHA with a non-Cartesian (radial) sampling scheme further decreases the aliasing energy for the parallel imaging algorithm to reconstruct, thereby further increasing the degree to which a multi-channel receiver array can be utilized for parallel imaging acceleration. In radial CAIPIRINHA, individual bands (slices) in a multislice excitation are modulated with view-dependent phase, causing a destructive interference of entire slices. This destructive interference leads to a reduction in aliasing compared to the coherent shifts one observes when using this same technique with a Cartesian trajectory. Recovery of each individual slice is possible because the applied phase pattern is known, and a conjugate-gradient reconstruction algorithm minimizes the contributions from other slices. Results are presented with a standard 12-channel head coil with acceleration factors up to 14, where radial CAIPIRINHA produces an improved reconstruction when compared with Cartesian CAIPIRINHA.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Algoritmos , Aumento da Imagem/métodos , Imageamento Tridimensional , Imageamento por Ressonância Magnética/instrumentação , Imagens de Fantasmas , Sensibilidade e Especificidade
7.
Magn Reson Med ; 66(6): 1682-8, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21523823

RESUMO

Previous work has shown that the use of radial GRAPPA for the reconstruction of undersampled real-time free-breathing cardiac data allows for frame rates of up to 30 images/s. It is well known that the spiral trajectory offers a higher scan efficiency compared to radial trajectories. For this reason, we have developed a novel through-time spiral GRAPPA method and demonstrate its application to real-time cardiac imaging. By moving from the radial trajectory to the spiral trajectory, the temporal resolution can be further improved at lower acceleration factors compared to radial GRAPPA. In addition, the image quality is improved compared to those generated using the radial trajectory due to the lower acceleration factor. Here, we show that 2D frame rates of up to 56 images/s can be achieved using this parallel imaging method with the spiral trajectory.


Assuntos
Algoritmos , Artefatos , Coração/anatomia & histologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imagem Cinética por Ressonância Magnética/métodos , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
8.
Adv Exp Med Biol ; 701: 193-9, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21445787

RESUMO

We present a novel approach to simultaneously measure, in vivo, noninvasively, glucose and oxygen consumption via Deuterium Magnetic Resonance (DMR). Mice are administered deuteriated glucose by intravenous injection. The rate of formation of nascent (deuteriated) mitochondrial water is then measured via DMR. The rate of glucose metabolism and oxygen utilization is assessed by tracking their separate peaks in DMR spectra during dynamic scanning. Further studies will aim to validate these results by comparison with in vivo (17)O-MRI (mitochondrial function), (13)C-MRI and (19)FDG-PET (glucose metabolism) and ex vivo 1H- and 2H-MR, as well as mass spectrometry.


Assuntos
Deutério/química , Imageamento por Ressonância Magnética , Consumo de Oxigênio , Oxigênio/metabolismo , Animais , Glucose/metabolismo , Masculino , Camundongos , Camundongos Nus
9.
Radiology ; 254(2): 449-59, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20089724

RESUMO

PURPOSE: To test the hypothesis that magnetic resonance (MR) imaging can be used to monitor both intraparenchymal injection of NaCl solution and subsequent radiofrequency ablation (RFA) within tissues pretreated with NaCl, report the low- and high-field-strength MR appearance of NaCl-enhanced RFAs, and compare MR findings with pathologic findings. MATERIALS AND METHODS: Ten ex vivo calf liver specimens were injected with saturated NaCl (seven were mixed with methylene blue during MR fluoroscopic monitoring) and reexamined with fast imaging with steady-state progression (FISP), true FISP, reversed FISP (PSIF), and fast spin-echo T2-weighted MR sequences. The NaCl-to-liver contrast-to-noise ratio (CNR) was calculated for various sequences, and CNRs were compared with the Student t test. Distribution on MR images was compared with the results of pathologic analysis. Forty additional in vivo monopolar RFAs were performed in paraspinal muscles of seven minipigs after animal care committee approval (10 standard control ablations, 30 were preceded by direct injection of saturated NaCl at various volumes [3-9 mL] and rates [1 or 6mL/min]). Postablation low-field-strength (n = 20) and high-field-strength (n = 20) MR examinations consisted of T2-weighted imaging, short inversion time inversion-recovery (STIR) imaging, and contrast material-enhanced T1-weighted imaging. Ablation shape, conspicuity, volume, and signal intensity were compared between the two groups and with the results of pathologic analysis. The difference in volumes with and without NaCl injection was evaluated by using two-way analysis of variance. RESULTS: Mean CNR was highest on fast spin-echo T2-weighted images and was significantly higher for PSIF than for FISP (P < .0001) or true FISP (P = .003). NaCl distribution on MR images corresponded with the results of pathologic analysis in ex vivo livers. Interactive in vivo monitoring of NaCl injection and electrode placement was feasible. NaCl-enhanced ablations had irregular shapes, a higher CNR, and significantly larger volumes (F = 22.0; df = 1, 90; P < .00001). All ablations had intermediate or low signal intensity with high-signal-intensity rims on all images. Fluid signals overlaid NaCl-enhanced ablations on fast spin-echo T2-weighted and STIR images, particularly on high-field-strength MR images. CONCLUSION: MR imaging can be used to reliably monitor the distribution of injected NaCl solution in tissues. Interventional MR imaging techniques can be used to guide and monitor RFAs within NaCl pretreated tissues, with good correlation with pathologic results.


Assuntos
Ablação por Cateter/métodos , Fígado/cirurgia , Imagem por Ressonância Magnética Intervencionista/métodos , Cloreto de Sódio/farmacologia , Análise de Variância , Animais , Bovinos , Humanos , Injeções , Modelos Animais , Cloreto de Sódio/administração & dosagem , Suínos
10.
Magn Reson Med ; 63(5): 1415-21, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20432314

RESUMO

Hypointense band artifacts occur at intersections of nonparallel imaging planes in rapidly acquired MR images; quantitative or numerical analysis of these bands and strategies to mitigate their appearance have largely gone unexplored. The magnetization evolution in the different regions of multiplanar images was simulated for three common rapid steady-state techniques (spoiled gradient echo, steady state free precession, balanced steady state free precession). Saturation banding was found to be highly dependent on the pulse sequence, acquisition time, and phase-encoding order. Encoding the center of k-space at the end of the acquisition of each slice (i.e., reverse centric phase encoding) is demonstrated to be a simple and robust method for significantly reducing the relative saturation in all imaging planes. View ordering and resolution dependence were confirmed in multiplanar abdominal images. The added importance of reducing the artifact in accelerated acquisition techniques (e.g., parallel imaging) is particularly notable in multiplanar balanced steady state free precession images in the brain.


Assuntos
Algoritmos , Artefatos , Encéfalo/patologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
11.
J Magn Reson Imaging ; 30(5): 1203-8, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19856456

RESUMO

PURPOSE: The goal of this study was to determine the effect of contrast media on the signal behavior of single-shot echo planar imaging (ssEPI) used for abdominal diffusion imaging. MATERIALS AND METHODS: The signal of an ssEPI spin echo sequence in a water phantom with varying concentrations of gadolinium was modeled with Bloch equations and the predicted behavior validated on a phantom at 1.5T. Six volunteers were given gadolinium contrast and signal intensity (SI) time courses for regions of interest (ROIs) in the liver, pancreas, spleen, renal cortex, and medulla were analyzed. Student's t-test was used to compare precontrast SI to 0, 1, 4, 5, 10, and 13 minutes following contrast. RESULTS: The results show that following contrast ssEPI SI goes through a nadir, recovering differently for each organ. Maximal contrast-related signal losses relative to precontrast signal are 20%, 20%, 53%, and 67% for the liver, pancreas, renal cortex, and medulla, respectively. The SIs remain statistically below the precontrast values for 5, 4, and 1 minute for the pancreas, liver, and spleen, and for all times measured for the renal cortex and medulla. CONCLUSION: Abdominal diffusion imaging should be performed prior to contrast due to adverse effects on the signal in ssEPI.


Assuntos
Abdome/patologia , Meios de Contraste/farmacologia , Imagem Ecoplanar/métodos , Diagnóstico por Imagem/métodos , Gadolínio/farmacologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Rim/patologia , Fígado/patologia , Imageamento por Ressonância Magnética/métodos , Pâncreas/patologia , Imagens de Fantasmas , Baço/patologia , Fatores de Tempo
12.
Magn Reson Med ; 60(2): 474-8, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18666134

RESUMO

Conventional Cartesian parallel MRI methods are limited to the sensitivity variations provided by the underlying receiver coil array in the dimension in which the data reduction is carried out, namely, the phase-encoding directions. However, in this work an acquisition strategy is presented that takes advantage of sensitivity variations in the readout direction, thus improving the parallel imaging reconstruction process. This is achieved by employing rapidly oscillating phase-encoding gradients during the actual readout. The benefit of this approach is demonstrated in vivo using various zigzag-shaped gradient trajectory designs. It is shown that zigzag type sampling, in analogy to CAIPIRINHA, modifies the appearance of aliasing in 2D and 3D imaging, thereby utilizing additional sensitivity variations in the readout direction directly resulting in improved parallel imaging reconstruction performance.


Assuntos
Algoritmos , Encéfalo/anatomia & histologia , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Imageamento por Ressonância Magnética/métodos , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
13.
AJR Am J Roentgenol ; 191(4): 1182-5, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18806162

RESUMO

OBJECTIVE: The purpose of this article is to introduce a technique for transrectal drainage of deep pelvic abscesses performed under interactive MRI guidance. CONCLUSION: A new method for triorthogonal image plane MRI guidance was developed and used to interactively monitor the puncture needle on continuously updated sets of adjustable three-plane images. The merits and limitations of the technique are highlighted and the patient population that is likely to benefit from this approach is suggested.


Assuntos
Abscesso/terapia , Drenagem/métodos , Imagem por Ressonância Magnética Intervencionista , Pelve , Abscesso/etiologia , Adenocarcinoma/complicações , Adenocarcinoma/cirurgia , Anastomose Cirúrgica/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Retais/complicações , Neoplasias Retais/cirurgia
14.
IEEE Trans Biomed Eng ; 55(3): 1004-14, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18334392

RESUMO

This study combines fast magnetic resonance imaging (MRI) and model simulation of tissue thermal ablation for monitoring and predicting the dynamics of lesion size for tumor destruction. In vivo experiments were conducted using radiofrequency (RF) thermal ablation in paraspinal muscle of rabbit with a VX2 tumor. Before ablation, turbo-spin echo (TSE) images visualized the 3-D tumor (necrotic core and tumor periphery) and surrounding normal tissue. MR gradient-recalled echo (GRE) phase and magnitude images were acquired repeatedly in 3.3 s at 30-s intervals during and after thermal ablation to follow tissue temperature distribution dynamics and lesion development in tumor and surrounding normal tissue. Final lesion sizes estimated from GRE magnitude, post-ablation TSE, and stained histologic images were compared. Model simulations of temperature distribution and lesion development dynamics closely corresponded to the experimental data from MR images in tumor and normal tissue. The combined use of MR image monitoring and model simulation has the potential for improving pretreatment planning and real-time prediction of lesion-size dynamics for guidance of thermal ablation of tumors.


Assuntos
Algoritmos , Hipertermia Induzida/métodos , Interpretação de Imagem Assistida por Computador/métodos , Armazenamento e Recuperação da Informação/métodos , Imagem por Ressonância Magnética Intervencionista/métodos , Neoplasias Musculares/patologia , Neoplasias Musculares/terapia , Animais , Simulação por Computador , Aumento da Imagem/métodos , Modelos Biológicos , Coelhos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Resultado do Tratamento
15.
AJR Am J Roentgenol ; 189(5): 1096-103, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17954646

RESUMO

OBJECTIVE: The objective of our study was to evaluate intraoperative low-field MRI for the frequency and duration of imaging sessions needed during surgery, the direct additional procedure time attributable to imaging, and the proportion of cases in which information provided by intraoperative MRI led to a change in the procedure or otherwise was deemed valuable by operating surgeons. MATERIALS AND METHODS: One hundred twenty-two patients (65 males, 57 females; age range, 6-77 years; mean age, 43.8 years) underwent 130 neurosurgical and ENT procedures (106 craniotomies, 17 transsphenoidal pituitary resections, three biopsies, three intracranial cyst aspirations or injections, and one skull base resection) in a specially designed surgical MRI suite equipped with a 0.2-T imager and a prototype rotating, tiltable surgical table. The intraoperative MR sequences included free induction with steady-state precession (fast imaging with steady-state precession [FISP]), steady-state free precession T2-weighted, reverse fast imaging with steady-state free precession (PSIF), FLASH, spin-echo T1-weighted, turbo spin-echo (TSE) T2-weighted, and TSE FLAIR. Each case was analyzed for the number of imaging sessions, duration of each session, total imaging time during surgery, and impact of imaging information on procedure. RESULTS: Each patient underwent between one and five intraor postoperative imaging sessions. Imaging times were 1.7 seconds-8 minutes 31 seconds per sequence. The mean total imaging time was 35 minutes 17 seconds per surgical procedure. Imaging was continuous during biopsy and cyst aspiration procedures and averaged 200.67 and 54.66 minutes, respectively. Additional surgical resection based on intraoperative imaging findings was performed in 72.8% of the cases. CONCLUSION: Intraoperative low-field MRI provides valuable information for surgical decision making that is predominantly related to detection of residual tumor and the exclusion of complications. The benefits of this technology surpass the time cost associated with its implementation when using proper imaging strategies.


Assuntos
Leitos , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/cirurgia , Aumento da Imagem/instrumentação , Imagem por Ressonância Magnética Intervencionista/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Aumento da Imagem/métodos , Imagem por Ressonância Magnética Intervencionista/métodos , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Rotação , Fatores de Tempo , Resultado do Tratamento
16.
Med Phys ; 33(3): 753-60, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16878577

RESUMO

We are investigating imaging techniques to study the tumor response to photodynamic therapy (PDT). Positron emission tomography (PET) can provide physiological and functional information. High-resolution magnetic resonance imaging (MRI) can provide anatomical and morphological changes. Image registration can combine MRI and PET images for improved tumor monitoring. In this study, we acquired high-resolution MRI and microPET 18F-fluorodeoxyglucose (FDG) images from C3H mice with RIF-1 tumors that were treated with Pc 4-based PDT. We developed two registration methods for this application. For registration of the whole mouse body, we used an automatic three-dimensional, normalized mutual information algorithm. For tumor registration, we developed a finite element model (FEM)-based deformable registration scheme. To assess the quality of whole body registration, we performed slice-by-slice review of both image volumes; manually segmented feature organs, such as the left and right kidneys and the bladder, in each slice; and computed the distance between corresponding centroids. Over 40 volume registration experiments were performed with MRI and microPET images. The distance between corresponding centroids of organs was 1.5 +/- 0.4 mm which is about 2 pixels of microPET images. The mean volume overlap ratios for tumors were 94.7% and 86.3% for the deformable and rigid registration methods, respectively. Registration of high-resolution MRI and microPET images combines anatomical and functional information of the tumors and provides a useful tool for evaluating photodynamic therapy.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Neoplasias/diagnóstico por imagem , Fotoquimioterapia/métodos , Tomografia por Emissão de Pósitrons/métodos , Animais , Automação , Modelos Animais de Doenças , Fluordesoxiglucose F18 , Imageamento Tridimensional , Rim/diagnóstico por imagem , Rim/patologia , Camundongos , Neoplasias/diagnóstico , Neoplasias/patologia , Radiografia , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Fatores de Tempo , Bexiga Urinária/diagnóstico por imagem , Bexiga Urinária/patologia , Contagem Corporal Total/veterinária
17.
Cancer Lett ; 229(2): 205-15, 2005 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-16115727

RESUMO

1,25-Dihydroxyvitamin D3 and several of its analogs, such as EB1089, induce growth arrest and apoptosis of breast cancer cells in culture. EB1089 has also been shown to limit growth of xenografts in nude mice and carcinogen-induced mammary tumors in rats. Coupled with the fact that the vitamin D receptor is highly expressed in a large proportion of breast tumors, these data suggest that it may be a broad spectrum therapeutic target. We utilized a transgenic model of hormone-induced mammary cancer, the LH-overexpressing mouse, to assess, for the first time, the efficacy of EB1089 in a spontaneous tumor model. Similar to human breast cancers, the pre-neoplastic mammary glands and mammary tumors in these mice express high levels of vitamin D receptor. Treatment with EB1089 decreased proliferation of mammary epithelial cells in pre-neoplastic glands by 35%. Moreover, half of hormone-induced mammary tumors treated with EB1089 demonstrated a decreased rate of growth, with a subset of these tumors even regressing, suggesting that 1,25-dihydroxyvitamin D3 analogs may be effective chemopreventive and chemotherapeutic agents for breast cancer.


Assuntos
Antineoplásicos/farmacologia , Calcitriol/análogos & derivados , Neoplasias Mamárias Experimentais/tratamento farmacológico , Lesões Pré-Cancerosas/tratamento farmacológico , Receptores de Calcitriol/agonistas , Animais , Calcitriol/farmacologia , Proliferação de Células/efeitos dos fármacos , Modelos Animais de Doenças , Feminino , Expressão Gênica/efeitos dos fármacos , Perfilação da Expressão Gênica , Imuno-Histoquímica , Hormônio Luteinizante/metabolismo , Neoplasias Mamárias Experimentais/patologia , Camundongos , Camundongos Transgênicos
18.
Acad Radiol ; 12(9): 1089-99, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16099690

RESUMO

Initial research in the development of interventional magnetic resonance (MR) imaging in the late 1980s and early to mid-1990s focused on pulse sequences, devices, and clinical applications. This focus was largely a result of the limited number of areas in which the academic research community leading the development could provide innovation on the MR systems of the time. However, during the past decade, computational power, higher bandwidth graphical displays, faster computer networks, improved pulse sequence architectures, and improved technical specifications have accelerated the pace of development on modern MR systems. Today, it is the combination of multiple system factors that are enabling the future of interventional MR. These developments, their impact on the field, and newly emerging applications are described.


Assuntos
Imageamento por Ressonância Magnética/tendências , Animais , Biópsia/métodos , Doenças Cardiovasculares/terapia , Ablação por Cateter , Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética/instrumentação , Punções
19.
Acad Radiol ; 12(7): 815-24, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16039535

RESUMO

RATIONALE AND OBJECTIVES: Three-dimensional (3D) nonrigid image registration for potential applications in prostate cancer treatment and interventional magnetic resonance (iMRI) imaging-guided therapies were investigated. MATERIALS AND METHODS: An almost fully automated 3D nonrigid registration algorithm using mutual information and a thin plate spline (TPS) transformation for MR images of the prostate and pelvis were created and evaluated. In the first step, an automatic rigid body registration with special features was used to capture the global transformation. In the second step, local feature points (FPs) were registered using mutual information. An operator entered only five FPs located at the prostate center, left and right hip joints, and left and right distal femurs. The program automatically determined and optimized other FPs at the external pelvic skin surface and along the femurs. More than 600 control points were used to establish a TPS transformation for deformation of the pelvic region and prostate. Ten volume pairs were acquired from three volunteers in the diagnostic (supine) and treatment positions (supine with legs raised). RESULTS: Various visualization techniques showed that warping rectified the significant pelvic misalignment by the rigid-body method. Gray-value measures of registration quality, including mutual information, correlation coefficient, and intensity difference, all improved with warping. The distance between prostate 3D centroids was 0.7 +/- 0.2 mm after warping compared with 4.9 +/- 3.4 mm with rigid-body registration. CONCLUSION: Semiautomatic nonrigid registration works better than rigid-body registration when patient position is changed greatly between acquisitions. It could be a useful tool for many applications in the management of prostate.


Assuntos
Imageamento Tridimensional , Imageamento por Ressonância Magnética/métodos , Pelve/patologia , Neoplasias da Próstata/patologia , Algoritmos , Fêmur/patologia , Humanos , Masculino , Neoplasias da Próstata/terapia
20.
Acad Radiol ; 12(9): 1085-8, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16112511

RESUMO

RATIONALE AND OBJECTIVES: The purpose of this study is to compare the feasibility and precision of renal artery angioplasty and stent placement using two different MR scanners. MATERIALS AND METHODS: MR imaging-guided angioplasty and stent placements were performed on seven pigs using 0.2 and 1.5 T scanners (Magnetom Open and Magnetom Sonata, Siemens Medical Solutions, Erlangen, Germany). For guidance of catheters, guide wires and stents susceptibility artifact-based tracking was used. The end point of each intervention was to position a stent in the renal artery with its proximal end at the level of the aortic wall. Procedure time and stent position were evaluated. RESULTS: Catheterization, angioplasty, and stent placement were feasible using MRI guidance at both 0.2 and 1,5 Tesla. At 1.5 T all catheter manipulations and interventions were performed in less than 30 minutes. At 0.2 T the interventions took up to 90 minutes. No significant difference in the stent deviation was noted between the two scanners. CONCLUSION: The use of a high-performance 1.5 T scanner helped to reduce the procedure time to half of that of a low-field system. Since no difference in stent placement precision was noted, a dedicated MR-stent might be mandatory for more precise stent placement.


Assuntos
Angioplastia com Balão , Imageamento por Ressonância Magnética/métodos , Obstrução da Artéria Renal/terapia , Stents , Animais , Meios de Contraste , Estudos de Viabilidade , Suínos
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