Detalhe da pesquisa
1.
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.
Proc Natl Acad Sci U S A
; 119(40): e2210779119, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36161945
2.
A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
Blood
; 140(19): 2053-2062, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35576529
3.
Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.
Haematologica
; 2024 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38450513
4.
Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Blood
; 138(13): 1172-1181, 2021 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34197597
5.
Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
Proc Natl Acad Sci U S A
; 117(26): 15018-15027, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527859
6.
Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.
Proc Natl Acad Sci U S A
; 114(5): E689-E696, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096387
7.
Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species.
Biochemistry
; 57(46): 6470-6478, 2018 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30375231
8.
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient ß-sheet.
Proc Natl Acad Sci U S A
; 110(48): 19285-90, 2013 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24218609
9.
Deamidation accelerates amyloid formation and alters amylin fiber structure.
J Am Chem Soc
; 134(30): 12658-67, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22734583
10.
Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.
J Phys Chem B
; 122(49): 11579-11590, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30179501
11.
Transition Dipoles from 1D and 2D Infrared Spectroscopy Help Reveal the Secondary Structures of Proteins: Application to Amyloids.
J Phys Chem B
; 119(44): 14065-75, 2015 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26446575
12.
2D IR cross peaks reveal hydrogen-deuterium exchange with single residue specificity.
J Phys Chem B
; 117(49): 15297-305, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659731
13.
Utilizing Lifetimes to Suppress Random Coil Features in 2D IR Spectra of Peptides.
J Phys Chem Lett
; 2(18): 2357-2361, 2011 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21966585