Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.
Int J Mol Sci
; 21(15)2020 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707880
4.
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS.
Neurobiol Dis
; 124: 340-352, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528255
5.
Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352.
Neurobiol Dis
; 132: 104558, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471201
6.
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Nat Neurosci
; 26(3): 416-429, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36635496
7.
CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5053, 2023 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598178
8.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469401
9.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Mol Neurodegener
; 17(1): 41, 2022 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35690868
10.
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Cell Death Differ
; 28(3): 915-931, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32994544
11.
Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1G93A mouse model of ALS.
Sci Rep
; 10(1): 15713, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32973290
12.
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
; 105(5): 837-854.e9, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902528
13.
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Sci Transl Med
; 12(545)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461331
14.
Author Correction: CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5516, 2023 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679403
15.
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.
Sci Rep
; 7: 44249, 2017 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28281673