Detalhe da pesquisa
1.
Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity.
Bioorg Med Chem Lett
; 28(21): 3463-3471, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290989
2.
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.
Xenobiotica
; 48(12): 1215-1226, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29182424
3.
Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.
Drug Metab Dispos
; 44(8): 1332-1340, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961241
4.
Identification of a novel series of potent HCV NS5B Site I inhibitors.
Bioorg Med Chem Lett
; 24(8): 1993-7, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656612
5.
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.
bioRxiv
; 2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711980
6.
Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F.
J Am Chem Soc
; 132(20): 7119-37, 2010 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20426477
7.
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm
; 8(4): 796-806, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108798
8.
Applications of Fluorine in Medicinal Chemistry.
J Med Chem
; 58(21): 8315-59, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26200936
9.
Diazonamide synthesis studies: use of Negishi coupling to fashion diazonamide-related biaryls with defined axial chirality.
Org Lett
; 4(20): 3525-8, 2002 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12323060
10.
Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates.
J Am Chem Soc
; 128(38): 12562-73, 2006 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16984207
11.
A proposal for the mechanism-of-action of diazoparaquinone natural products.
J Am Chem Soc
; 127(44): 15344-5, 2005 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16262378