Detalhe da pesquisa
1.
In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.
Cell
; 172(4): 696-705.e12, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29398115
2.
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
EMBO J
; 41(8): e108443, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35112738
3.
C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.
EMBO Rep
; 24(8): e55895, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37317656
4.
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
EMBO J
; 39(8): e102811, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32175624
5.
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
EMBO Rep
; 23(6): e53890, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35438230
6.
The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene.
J Biol Chem
; 297(4): 101120, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450161
7.
Clinico-genetic findings in 509 frontotemporal dementia patients.
Mol Psychiatry
; 26(10): 5824-5832, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34561610
8.
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
EMBO Rep
; 21(10): e50241, 2020 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929860
9.
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
EMBO J
; 35(21): 2350-2370, 2016 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621269
10.
Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3.
Acta Neuropathol
; 139(1): 99-118, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31642962
11.
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
Acta Neuropathol
; 140(2): 121-142, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32562018
12.
Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
Hum Mol Genet
; 26(4): 790-800, 2017 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28040728
13.
Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
Acta Neuropathol
; 137(6): 879-899, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30739198
14.
The ER under rapid fire.
EMBO J
; 33(11): 1195-7, 2014 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24788411
15.
MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.
EMBO J
; 33(15): 1667-80, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25001178
16.
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.
EMBO J
; 33(5): 450-67, 2014 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24357581
17.
Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
EMBO Rep
; 17(9): 1314-25, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27461252
18.
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
J Biol Chem
; 291(1): 318-33, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26574544
19.
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
Acta Neuropathol
; 134(2): 241-254, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28409281
20.
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
Acta Neuropathol
; 131(4): 587-604, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26895297